Targeting the stem cell niche micro-environment as therapeutic strategies in aging

R Farahzadi, B Valipour, S Montazersaheb… - Frontiers in cell and …, 2023 - frontiersin.org
Adult stem cells (ASCs) reside throughout the body and support various tissue. Owing to
their self-renewal capacity and differentiation potential, ASCs have the potential to be used …

[HTML][HTML] Therapeutic potential of natural killer cells in neuroimmunological diseases

Q Zhang, J Lin, M Yang, Z Li, M Zhang, B Bu - Biomedicine & …, 2024 - Elsevier
Natural killer (NK) cells, a major component of the innate immune system, have prominent
immunoregulatory, antitumor proliferation, and antiviral activities. NK cells act as a double …

[HTML][HTML] Investigating the dynamic interplay between Cellular Immunity and Tumor cells in the Fight Against Cancer: an updated Comprehensive Review

SA Aghapour, M Torabizadeh, SS Bahreiny… - Iranian Journal of Blood …, 2024 - ijbc.ir
The dynamic interplay between cellular immunity and tumor cells is essential in cancer
advancement and response to therapy. This updated, comprehensive review examines the …

Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis

W Wen, X Chen, XY Shen, HY Li, F Zhang… - Stem Cell Research & …, 2023 - Springer
Background Natural killer (NK) cells hold great promise in treating diverse hematopoietic
and solid tumors. Despite their availability from peripheral blood and cord blood, stem cell …

The RNA-binding protein CMSS1 promotes the progression of non-small cell lung cancer by regulating the telomerase protein subunit hTERT

W Gu, H Li, L Sun, Z Shen, Y Wang, X Hu, Y Wu, W Liu… - Life Sciences, 2025 - Elsevier
Aims High telomerase activity has been detected in over 85% of tumors, with the activation
of hTERT being the most crucial mechanism for re-establishing telomerase activity …

Modulation of biological activities in adipose derived stem cells by histone deacetylation

S Abdallah, M Tabebi, S Qanadilo, N Ali, J Wang… - Scientific Reports, 2025 - nature.com
Difficult-to-heal wounds management accounts for about 4% of healthcare costs,
highlighting the need for innovative solutions. Extracellular signals drive cell proliferation …

Strong capacity of differentiated PD-L1 CAR-modified UCB-CD34+ cells and PD-L1 CAR-modified UCB-CD34+-derived NK cells in killing target cells and restoration …

F Ghaedrahmati, V Akbari… - Stem Cell Research & …, 2024 - Springer
Background Using natural killer (NK) cells to treat hematopoietic and solid tumors has great
promise. Despite their availability from peripheral blood and cord blood, stem cell-derived …

The circular RNA circFOXK2 enhances the tumorigenesis of non-small cell lung cancer through the miR-149-3p/IL-6 Axis

T **ang, L Chen, H Wang, T Yu, T Li, J Li, W Yu - Biochemical Genetics, 2024 - Springer
Circular RNAs (circRNAs) are the non-coding types of RNAs and are thoughts to be linked
with human cancer progression. circFOXK2 is believed to be associated with cancers …

CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration …

Y Zhang, S Yang, X You, Z Li, L Chen, R Dai… - Stem Cell Research & …, 2025 - Springer
Background The microenvironment of intervertebral disc degeneration (IVDD) is
characterized by oxidative stress, leading to the senescence of nucleus pulposus-derived …

[HTML][HTML] Ginsenoside Rg1 promotes fetal hemoglobin production in vitro: A potential therapeutic avenue for β-thalassemia

DL Cai, Y Chan, YM Kong, YZ Liu, Y Guo… - European Journal of …, 2024 - Elsevier
Abstract β-thalassemia, a globally prevalent genetic disorder, urgently requires innovative
treatment options. Fetal hemoglobin (HbF) induction stands as a key therapeutic approach …