Structure, dynamics and lipid interactions of serotonin receptors: excitements and challenges
Abstract Serotonin (5-hydroxytryptamine, 5-HT) is an intrinsically fluorescent
neurotransmitter found in organisms spanning a wide evolutionary range. Serotonin exerts …
neurotransmitter found in organisms spanning a wide evolutionary range. Serotonin exerts …
Targeting VIP and PACAP receptor signaling: new insights into designing drugs for the PACAP subfamily of receptors
Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Vasoactive Intestinal Peptide
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …
Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
X Wang, C Neale, SK Kim, WA Goddard… - Nature Communications, 2023 - nature.com
Understanding the roles of intermediate states in signaling is pivotal to unraveling the
activation processes of G protein-coupled receptors (GPCRs). However, the field is still …
activation processes of G protein-coupled receptors (GPCRs). However, the field is still …
Detergent-free lipodisq nanoparticles facilitate high-resolution mass spectrometry of folded integral membrane proteins
Integral membrane proteins pose considerable challenges to mass spectrometry (MS) owing
to the complexity and diversity of the components in their native environment. Here, we use …
to the complexity and diversity of the components in their native environment. Here, we use …
Lipid nanoparticle technologies for the study of G protein-coupled receptors in lipid environments
S Lavington, A Watts - Biophysical Reviews, 2020 - Springer
G protein-coupled receptors (GPCRs) are a large family of integral membrane proteins
which conduct a wide range of biological roles and represent significant drug targets. Most …
which conduct a wide range of biological roles and represent significant drug targets. Most …
Capturing peptide–GPCR interactions and their dynamics
A Kaiser, I Coin - Molecules, 2020 - mdpi.com
Many biological functions of peptides are mediated through G protein-coupled receptors
(GPCRs). Upon ligand binding, GPCRs undergo conformational changes that facilitate the …
(GPCRs). Upon ligand binding, GPCRs undergo conformational changes that facilitate the …
Pyroglutamination-Induced Changes in the Physicochemical Features of a CXCR4 Chemokine Peptide: Kinetic and Structural Analysis
MML Ferreira, SEG de Souza, CC da Silva… - Biochemistry, 2023 - ACS Publications
We investigate the physicochemical effects of pyroglutamination on the QHALTSV-NH2
peptide, a segment of cytosolic helix 8 of the human C–X–C chemokine G-protein-coupled …
peptide, a segment of cytosolic helix 8 of the human C–X–C chemokine G-protein-coupled …
Molecular insights into mechanisms of GPCR hijacking by Staphylococcus aureus
CM Grison, P Lambey, S Jeannot… - Proceedings of the …, 2021 - National Acad Sciences
Atypical chemokine receptor 1 (ACKR1) is a G protein–coupled receptor (GPCR) targeted by
Staphylococcus aureus bicomponent pore-forming leukotoxins to promote bacterial growth …
Staphylococcus aureus bicomponent pore-forming leukotoxins to promote bacterial growth …
Control of G protein–coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains
CD Mancinelli, DC Marx… - Proceedings of the …, 2024 - pnas.org
G protein–coupled receptors (GPCRs) control intracellular signaling cascades via agonist-
dependent coupling to intracellular transducers including heterotrimeric G proteins, GPCR …
dependent coupling to intracellular transducers including heterotrimeric G proteins, GPCR …
Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors
G Protein-coupled receptors (GPCRs) are the most frequently exploited drug target family,
moreover they are often found mutated in cancer. Here we used a dataset of mutations …
moreover they are often found mutated in cancer. Here we used a dataset of mutations …