Tuberculosis drug discovery: challenges and new horizons
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
Hit generation in TB drug discovery: from genome to granuloma
Current tuberculosis (TB) drug development efforts are not sufficient to end the global TB
epidemic. Recent efforts have focused on the development of whole-cell screening assays …
epidemic. Recent efforts have focused on the development of whole-cell screening assays …
High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds
Rapidly spreading antibiotic resistance and the low discovery rate of new antimicrobial
compounds demand more effective strategies for early drug discovery. One bottleneck in the …
compounds demand more effective strategies for early drug discovery. One bottleneck in the …
Pipeline of anti‐Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities
The Mycobacterium abscessus complex is a group of emerging pathogens that are difficult
to treat. There are no effective drugs for successful M. abscessus pulmonary infection …
to treat. There are no effective drugs for successful M. abscessus pulmonary infection …
Identification of KasA as the cellular target of an anti-tubercular scaffold
KA Abrahams, C Chung, S Ghidelli-Disse… - Nature …, 2016 - nature.com
Phenotypic screens for bactericidal compounds are starting to yield promising hits against
tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants …
tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants …
Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
Screening of TB actives for activity against nontuberculous mycobacteria delivers high hit rates
The prevalence of lung disease due to infections with nontuberculous mycobacteria (NTM)
has been increasing and surpassed tuberculosis (TB) in some countries. Treatment …
has been increasing and surpassed tuberculosis (TB) in some countries. Treatment …
Unpacking the Pathogen Box—an open source tool for fighting neglected tropical disease
CGL Veale - ChemMedChem, 2019 - Wiley Online Library
Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …
their potential against several of the world's most important neglected tropical diseases …
Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface
Drug discovery efforts against the pathogen Mycobacterium tuberculosis (Mtb) have been
advanced through phenotypic screens of extensive compound libraries. Such a screen …
advanced through phenotypic screens of extensive compound libraries. Such a screen …
Piperidine-4-carboxamides target DNA gyrase in Mycobacterium abscessus
New, more-effective drugs for the treatment of lung disease caused by nontuberculous
mycobacteria (NTM) are needed. Among NTM opportunistic pathogens, Mycobacterium …
mycobacteria (NTM) are needed. Among NTM opportunistic pathogens, Mycobacterium …