Altered metabolism in cancer: Insights into energy pathways and therapeutic targets
M Tufail, CH Jiang, N Li - Molecular Cancer, 2024 - Springer
Cancer cells undergo significant metabolic reprogramming to support their rapid growth and
survival. This study examines important metabolic pathways like glycolysis, oxidative …
survival. This study examines important metabolic pathways like glycolysis, oxidative …
Targeting ribosome biogenesis in cancer: lessons learned and way forward
A Zisi, J Bartek, MS Lindström - Cancers, 2022 - mdpi.com
Simple Summary Cells need to produce ribosomes to sustain continuous proliferation and
expand in numbers, a feature that is even more prominent in uncontrollably proliferating …
expand in numbers, a feature that is even more prominent in uncontrollably proliferating …
A novel Alzheimer's disease prognostic signature: identification and analysis of glutamine metabolism genes in immunogenicity and immunotherapy efficacy
Z Wu, P Liu, B Huang, S Deng, Z Song, X Huang… - Scientific Reports, 2023 - nature.com
Alzheimer's disease (AD) is characterized as a distinct onset and progression of cognitive
and functional decline associated with age, as well as a specific neuropathology. It has been …
and functional decline associated with age, as well as a specific neuropathology. It has been …
Metabolic changes during prostate cancer development and progression
Metabolic reprogramming has been recognised as a hallmark in solid tumours. Malignant
modification of the tumour's bioenergetics provides energy for tumour growth and …
modification of the tumour's bioenergetics provides energy for tumour growth and …
Glutamine imaging: a new avenue for glioma management
S Ekici, JA Nye, SG Neill, JW Allen… - American Journal …, 2022 - Am Soc Neuroradiology
The glutamine pathway is emerging as an important marker of cancer prognosis and a target
for new treatments. In gliomas, the most common type of brain tumors, metabolic …
for new treatments. In gliomas, the most common type of brain tumors, metabolic …
Bioinformatics and machine learning were used to validate glutamine metabolism-related genes and immunotherapy in osteoporosis patients
L Wang, C Deng, Z Wu, K Zhu, Z Yang - Journal of Orthopaedic Surgery …, 2023 - Springer
Background Osteoporosis (OP), often referred to as the “silent disease of the twenty-first
century,” poses a significant public health concern due to its severity, chronic nature, and …
century,” poses a significant public health concern due to its severity, chronic nature, and …
[HTML][HTML] S-Nitrosylation at the intersection of metabolism and autophagy: Implications for cancer
S Guil-Luna, MT Sanchez-Montero… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Metabolic plasticity, which determines tumour growth and metastasis, is now understood to
be a flexible and context-specific process in cancer metabolism. One of the major pathways …
be a flexible and context-specific process in cancer metabolism. One of the major pathways …
Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3β/β-catenin/EMT pathway
Z Tan, K Boyapati, CM Tressler, NM Jenkinson… - Cancer Letters, 2024 - Elsevier
Breast cancer is the leading cancer-related cause of death in women. Here we show that
solute carrier family 38-member 3 (SLC38A3) is overexpressed in breast cancer, particularly …
solute carrier family 38-member 3 (SLC38A3) is overexpressed in breast cancer, particularly …
A novel small-molecule inhibitor of SREBP-1 based on natural product monomers upregulates the sensitivity of lung squamous cell carcinoma cells to antitumor drugs
DB Ma, XY Liu, H Jia, Y Zhang, Q Jiang… - Frontiers in …, 2022 - frontiersin.org
The transcription factor, sterol regulatory element binding protein 1 (SREBP-1), plays
important roles in modulating the proliferation, metastasis, or resistance to antitumor agents …
important roles in modulating the proliferation, metastasis, or resistance to antitumor agents …
Metabolic reservoir cycles in cancer
C Zhang, A Quinones, A Le - Seminars in cancer biology, 2022 - Elsevier
Cancer cells possess various biological processes to ensure survival and proliferation even
under unfavorable conditions such as hypoxia, nutrient deprivation, and oxidative stress …
under unfavorable conditions such as hypoxia, nutrient deprivation, and oxidative stress …