The multifaceted effects of non-steroidal and non-opioid anti-inflammatory and analgesic drugs on platelets: current knowledge, limitations, and future perspectives

A Tsoupras, DA Gkika, I Siadimas… - Pharmaceuticals, 2024‏ - mdpi.com
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely utilized
pharmaceuticals worldwide. Besides their recognized anti-inflammatory effects, these drugs …

Cool the inflamed brain: A novel anti-inflammatory strategy for the treatment of major depressive disorder

WJ Su, T Hu, CL Jiang - Current Neuropharmacology, 2024‏ - benthamdirect.com
Background: Abundant evidence suggests that inflammatory cytokines contribute to the
symptoms of major depressive disorder (MDD) by altering neurotransmission …

Induction of mitochondrial toxicity by non-steroidal anti-inflammatory drugs (NSAIDs): The ultimate trade-off governing the therapeutic merits and demerits of these …

S Mazumder, S Bindu, S Debsharma… - Biochemical …, 2024‏ - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) are most extensively used over-the-counter
FDA-approved analgesic medicines for treating inflammation, musculoskeletal pain, arthritis …

Revisiting and updating the interaction between human serum albumin and the non-steroidal anti-inflammatory drugs ketoprofen and ketorolac

RS Cunha, PF Cruz, T Costa, ZL Almeida, MEF Lima… - Molecules, 2024‏ - mdpi.com
Ketoprofen (KTF) and ketorolac (KTL) are among the most primarily used non-steroidal anti-
inflammatory drugs (NSAIDs) in humans to alleviate moderate pain and to treat …

[HTML][HTML] Non-steroidal anti-inflammatory drugs administered intra-articularly in temporomandibular joint disorders: a systematic review and meta-analysis

F Bliźniak, M Chęciński, K Chęcińska… - Journal of Clinical …, 2024‏ - mdpi.com
Objectives: This systematic review was designed to summarize randomized controlled trials
of intra-articular administration of non-steroidal anti-inflammatory drugs (NSAIDs) for …

Improving the treatment of bacterial infections caused by multidrug-resistant bacteria through drug repositioning

P Glajzner, A Bernat… - Frontiers in …, 2024‏ - frontiersin.org
Drug repurposing (repositioning) is a dynamically-develo** area in the search for effective
therapy of infectious diseases. Repositioning existing drugs with a well-known …

Gold (I) complexes based on nonsteroidal anti-inflammatory derivatives as multi-target drugs against colon cancer

J Saez, J Quero, MJ Rodriguez-Yoldi… - Inorganic …, 2024‏ - ACS Publications
Targeting inflammation and the molecules involved in the inflammatory process could be an
effective cancer prevention and therapy strategy. Therefore, the use of anti-inflammatory …

Sco** review of interventions to de-implement potentially harmful non-steroidal anti-inflammatory drugs (NSAIDs) in healthcare settings

MS Rockwell, EG Oyese, E Singh, M Vinson, I Yim… - BMJ open, 2024‏ - bmjopen.bmj.com
Objectives Potentially harmful non-steroidal anti-inflammatory drugs (NSAIDs) utilisation
persists at undesirable rates worldwide. The purpose of this paper is to review the literature …

[HTML][HTML] Drug repurposing for cancer treatment: A comprehensive review

AH Al Khzem, MS Gomaa, MS Alturki… - International …, 2024‏ - pmc.ncbi.nlm.nih.gov
Cancer ranks among the primary contributors to global mortality. In 2022, the global
incidence of new cancer cases reached about 20 million, while the number of cancer-related …

Antimicrobial effect of pimozide by targeting ROS‐mediated killing in Staphylococcus aureus

S Kumar, K Sandeep, R Kumar… - Biotechnology and …, 2023‏ - Wiley Online Library
In spite of the higher nosocomial and community‐acquired infections caused by
Staphylococcus aureus, emerging drug resistance is a leading cause of increased mortality …