Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders
SM Stanford, N Bottini - Nature Reviews Drug Discovery, 2023 - nature.com
Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …
attractive therapeutic targets for various diseases. Although extensive effort has been …
Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets
KW Finnson, Y Almadani, A Philip - Seminars in cell & developmental …, 2020 - Elsevier
Transforming growth factor (TGF)-β uses several intracellular signaling pathways besides
canonical ALK5-Smad2/3 signaling to regulate a diverse array of cellular functions. Several …
canonical ALK5-Smad2/3 signaling to regulate a diverse array of cellular functions. Several …
Evolving insights into the cellular and molecular pathogenesis of fibrosis in systemic sclerosis
B Korman - Translational Research, 2019 - Elsevier
Systemic sclerosis (SSc, scleroderma) is a complex multisystem disease characterized by
autoimmunity, vasculopathy, and most notably, fibrosis. Multiple lines of evidence …
autoimmunity, vasculopathy, and most notably, fibrosis. Multiple lines of evidence …
SMAD4 activates Wnt signaling pathway to inhibit granulosa cell apoptosis
X Du, Q Li, L Yang, L Liu, Q Cao, Q Li - Cell Death & Disease, 2020 - nature.com
The TGF-β and Wnt signaling pathways are interrelated in many cell types and tissues, and
control cell functions in coordination. Here, we report that SMAD4, a downstream effector of …
control cell functions in coordination. Here, we report that SMAD4, a downstream effector of …
Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal
Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA)
pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through …
pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through …
[PDF][PDF] One year in review 2018: systemic sclerosis
M Orlandi, S Barsotti, G Lepri, V Codullo… - Clin Exp …, 2018 - researchgate.net
Systemic sclerosis is a rare acquired systemic disease characterised by a complex
pathogenesis and multi organ involvement. Every year the scientific world contributes to …
pathogenesis and multi organ involvement. Every year the scientific world contributes to …
Physiological and oncogenic roles of the PRL phosphatases
S Hardy, E Kostantin, T Hatzihristidis… - The FEBS …, 2018 - Wiley Online Library
The human Phosphatase of Regenerative Liver (PRL) family comprises three members
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
To survive, mammalian cells must adapt to environmental challenges. While the cellular
response to mild stress has been widely studied, how cells respond to severe stress remains …
response to mild stress has been widely studied, how cells respond to severe stress remains …
PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth
Phosphatases of regenerating liver (PRLs) are markers of cancer and promote tumor
growth. They have been implicated in a variety of biochemical pathways but the …
growth. They have been implicated in a variety of biochemical pathways but the …
PTP4A1 promotes oral squamous cell carcinoma (OSCC) metastasis through altered mitochondrial metabolic reprogramming
B Liu, W Si, B Wei, X Zhang, P Chen - Cell Death Discovery, 2023 - nature.com
PTP4A1 (Protein tyrosine phosphatase 4A1) is a protein tyrosine phosphatase that regulates
a range of pro-oncogenic signaling pathways. Here, we report a novel role for PTP4A1 in …
a range of pro-oncogenic signaling pathways. Here, we report a novel role for PTP4A1 in …