Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …

As a member of the vertebrate-specific secreted ribonucleases, angiogenin (ANG) was first
isolated and identified solely by its ability to induce new blood vessel formation, and now, it …

The discovery of microRNA (miRNA) sorting into extracellular vesicles (EVs) revealed a
novel mode of intercellular communication and uncovered a link between cellular …

Mitochondrial DNA (mtDNA) released through protein oligomers, such as voltage-
dependent anion channel 1 (VDAC1), triggers innate immune activation and thus …

Simple Summary Patients with unresectable hepatocellular carcinoma (HCC), the most
common primary tumor of the liver, have poor prognosis and are increasing worldwide. The …

Pancreatic-type ribonucleases (ptRNases) are a large family of vertebrate-specific secretory
endoribonucleases. These enzymes catalyze the degradation of many RNA substrates and …

Background and Purpose—Endothelial progenitor cells (EPCs) have been extensively
investigated as a therapeutic approach for repairing the vascular system in cerebrovascular …

Simple Summary In the past decade, tyrosine kinase inhibitors sorafenib and regorafenib
have been standard treatments for advanced liver cancer. Previous studies have associated …

Background and Aims GAS6 signaling, through the TAM receptor tyrosine kinases AXL and
MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM …

Abstract Capsaicin (trans-8-methyl-N-vanillyl-6-noneamide) is a hydrophobic, lipophilic
vanilloid phytochemical abundantly found in chili peppers and pepper extracts. Several …