Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension
T Thenappan, SY Chan… - American Journal of …, 2018 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is characterized by remodeling of the extracellular
matrix (ECM) of the pulmonary arteries with increased collagen deposition, cross-linkage of …
matrix (ECM) of the pulmonary arteries with increased collagen deposition, cross-linkage of …
The role of hypoxia-inducible factors in cardiovascular diseases
B Yu, X Wang, Y Song, G ** secondarily in pulmonary fibrosis (PF) patients
(PF-PH) is a frequent co-morbidity. The high prevalence of PH in PF patients is very …
(PF-PH) is a frequent co-morbidity. The high prevalence of PH in PF patients is very …
[HTML][HTML] Extracellular matrix stiffness in lung health and disease
T Guo, C He, A Venado, Y Zhou - Comprehensive Physiology, 2022 - ncbi.nlm.nih.gov
The extracellular matrix (ECM) provides structural support and imparts a wide variety of
environmental cues to cells. In the past decade, a growing body of work revealed that the …
environmental cues to cells. In the past decade, a growing body of work revealed that the …
Hypoxia triggers osteochondrogenic differentiation of vascular smooth muscle cells in an HIF-1 (hypoxia-inducible factor 1)–dependent and reactive oxygen species …
Objective—Vascular calcification is associated with high risk of cardiovascular events and
mortality. Osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) is the …
mortality. Osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) is the …
Translating research into improved patient care in pulmonary arterial hypertension
We have witnessed significant advances in the management of pulmonary arterial
hypertension (PAH)(1), a rare and severe condition characterized by intense pulmonary …
hypertension (PAH)(1), a rare and severe condition characterized by intense pulmonary …