Genome editing has been a transformative force in the life sciences and human medicine,
offering unprecedented opportunities to dissect complex biological processes and treat the …

Cancer is a disease that stems from a fundamental liability inherent to multicellular life forms
in which an individual cell is capable of reneging on the interests of the collective organism …

Cancer is the second leading cause of death worldwide and disease burden is expected to
increase globally throughout the next several decades, with the majority of cancer-related …

Recording molecular information to genomic DNA is a powerful means of investigating
topics ranging from multicellular development to cancer evolution. With molecular recording …

Defining the initial events in oncogenesis and the cellular responses they entrain, even in
advance of morphologic abnormality, is a fundamental challenge in understanding cancer …

Tumor progression is driven by dynamic interactions between cancer cells and their
surrounding microenvironment. Investigating the spatiotemporal evolution of tumors can …

The evolution of metastasis, the spread of cancer to distal sites within the body, represents a
lethal stage of cancer progression. Yet, the evolutionary dynamics that shape the …

Lineage tracing has significantly advanced our comprehension in many areas of biology,
such as development or immunity, by precisely measuring cellular processes like migration …

Understanding cellular birth rate differences is crucial for predicting cancer progression and
interpreting tumor-derived genetic data. Lineage tracing experiments enable detailed …

Single-cell lineage tracing technology has advanced the investigation of progenitor cells'
development using static, inheritable barcodes. It can determine temporal dynamics in …