Adrenal insufficiency can arise from a primary adrenal disorder, secondary to
adrenocorticotropic hormone deficiency, or by suppression of adrenocorticotropic hormone …

Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …

Adrenal insufficiency (AI) is a condition characterized by an absolute or relative deficiency of
adrenal cortisol production. Primary AI (PAI) is rare and is caused by direct adrenal failure …

Adrenal insufficiency is the clinical manifestation of deficient production or action of
glucocorticoids, with or without deficiency also in mineralocorticoids and adrenal androgens …

Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …

Objective: Primary adrenal insufficiency [Addison's disease (AD)] is rare, and systematic
studies are few, mostly conducted on small patient samples. We aimed to determine the …

Context: Patients with treated adrenal insufficiency (AI) have increased morbidity and
mortality rate. Our goal was to improve outcome by develo** a once-daily (OD) oral …

Background Conventional treatment of patients with adrenal insufficiency involves
administration of glucocorticoids multiple times a day and has been associated with weight …

Cushing's syndrome (CS) is a severe condition that results from chronic exposure to
elevated circulating cortisol levels; it is a rare but potentially life-threating condition …

The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …