Background The circulating form of human endoglin (sEng) is a cleavage product of
membrane-bound endoglin present on endothelial cells. Because sEng encompasses an …

Congenital adrenal hyperplasia is an inherited autosomal recessive disorder related to
deficient cortisol synthesis. The deficiency of steroid 21-hydroxylase (cytochrome P450 …

The transcriptional regulator PehR regulates the synthesis of the extracellular plant cell wall-
degrading enzyme polygalacturonase, which is essential in the bacterial wilt of plants …

Adenylyl cyclases (ACs) play a key role in many signaling cascades. ACs catalyze the
production of cyclic AMP from ATP and this function is stimulated or inhibited by the binding …

Dyslipidemia is an umbrella term for a range of lipid metabolic disorders in the body. This
condition has been widely reported to greatly increase the risk of cardiovascular diseases …

Friedreich's Ataxia (FRDA) stands out as the most prevalent form of hereditary ataxias,
marked by progressive movement ataxia, loss of vibratory sensitivity, and skeletal …

Mollusks have recently received increasing attention because of their unique immune
systems. Mollusks such as Amphioctopus fangsiao are economically important …

Structural insights into the photoactivated adenylate cyclases can be used to develop new
ways of controlling cellular cyclic adenosine monophosphate (cAMP) levels for optogenetic …

Long-term potentiation and depression of synaptic activity in response to stimuli is a key
factor in reinforcement learning. Strengthening of the corticostriatal synapses depends on …

Objectives: To evaluate the pharmacodynamical effects and pharmacological mechanism of
Ginsenoside H drip** pills (GH) in chronic unpredictable mild stress (CUMS) model rats …