Biomarkers can help unravel mechanisms of disease and identify new targets for therapy.
They can also be useful in clinical practice for monitoring disease progression, evaluation of …

Abstract Paraoxonase 1 (PON1), a component of high-density lipoprotein (HDL), is a
calcium-dependent multifunctional enzyme that connects metabolisms of lipoproteins and …

Purpose: Metformin is a biguanide derivative that is commonly used for the treatment of
diabetes mellitus (DM). It demonstrates antioxidative, anti-inflammatory, and antiangiogenic …

Mild to moderate hyperhomocysteinemia is prevalent in humans and is implicated in
neurovascular diseases, including recently in certain retinal diseases. Herein, we used …

There is still no agreement on total plasma homocysteine (tH cy) role in age‐related macular
degeneration (AMD), the leading cause of new blindness in industrialized countries. We …

HDL-associated paraoxonase 1 (PON1) activity has been consistently associated with
cardiovascular and other diseases. Vitamins C and E intake have previously been positively …

Although AMD is a complex disease, oxidative stress is a crucial contributor to its
development, especially in view of the higher oxygen demand of the retina. Paraoxonase 2 …

Age‐related macular degeneration (AMD) is a common and severe blinding disease among
people worldwide. Retinal inflammation and neovascularization are two fundamental …

This study provides diverse lines of evidence demonstrating that fluoride (F) exposure
contributes to degenerative eye diseases by stimulating or inhibiting biological pathways …

Background. Paraoxonase 1 (PON1) enzymatic activity has been consistently predictive of
cardiovascular disease, while the genotypes at the four functional polymorphisms at PON1 …