Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view
Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …
compacta and subsequent reduction of dopamine levels in striatum are associated with …
Patient-specific iPSC-derived astrocytes contribute to non-cell-autonomous neurodegeneration in Parkinson's disease
Parkinson's disease (PD) is associated with the degeneration of ventral midbrain
dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell …
dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell …
Mitophagy in human diseases
L Doblado, C Lueck, C Rey, AK Samhan-Arias… - International journal of …, 2021 - mdpi.com
Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …
Phagocytosis in the brain: homeostasis and disease
Microglia are resident macrophages of the central nervous system and significantly
contribute to overall brain function by participating in phagocytosis during development …
contribute to overall brain function by participating in phagocytosis during development …
Structural analysis of the full-length human LRRK2
Mutations in leucine-rich repeat kinase 2 (LRRK2) are commonly implicated in the
pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 regulates …
pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 regulates …
Functional impairment in miro degradation and mitophagy is a shared feature in familial and sporadic Parkinson's disease
CH Hsieh, A Shaltouki, AE Gonzalez, AB da Cruz… - Cell stem cell, 2016 - cell.com
Mitochondrial movements are tightly controlled to maintain energy homeostasis and prevent
oxidative stress. Miro is an outer mitochondrial membrane protein that anchors mitochondria …
oxidative stress. Miro is an outer mitochondrial membrane protein that anchors mitochondria …
[HTML][HTML] Exploring the journey of emodin as a potential neuroprotective agent: novel therapeutic insights with molecular mechanism of action
Emodin is an anthraquinone derivative found in the roots and bark of a variety of plants,
molds, and lichens. Emodin has been used as a traditional medication for more than 2000 …
molds, and lichens. Emodin has been used as a traditional medication for more than 2000 …
Oxidative stress and cellular pathologies in Parkinson's disease
Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …
The two-century journey of Parkinson disease research
S Przedborski - Nature Reviews Neuroscience, 2017 - nature.com
Since the first formal description of Parkinson disease (PD) two centuries ago, our
understanding of this common neurodegenerative disorder has expanded at all levels of …
understanding of this common neurodegenerative disorder has expanded at all levels of …