Publisher Summary This chapter focuses on the cellular and intracellular basis for impaired
immunologic activity. The activation of B and T cells, transit through the cell cycle, and …

The history of glucocorticosteroid therapy and modern rheumatology are inseparable.
Glucocortico-steroids exert profound effects on the inflammatory and immune responses …

In transgenic mice, mature peripheral B lymphocytes in lymphoid follicles, like immature B
cells, are rendered tolerant by encounter with self-antigen, provided receptor occupancy by …

B lymphocytes recognize antigen through membrane-bound antigen-receptors, membrane
IgM and IgD (mIgM and mIgD). Binding to foreign antigens initiates a cascade of …

Engagement of surface immunoglobulin on mature B cells leads to rescue from apoptosis
and to proliferation. Levels of bcl-2 mRNA and protein increase with cross-linking of surface …

To study the fate of develo** B cells in the presence and absence of the autoantigens to
which they react, chimeric mice were constructed by injecting bone marrow cells from mice …

The two major classes of antigen receptors on murine B lymphocytes, mIgM and mIgD, are
both contained in a complex with two additional molecules, Ig‐alpha and Ig‐beta, which …

An important function of the low affinity IgG Fc receptor FcRII‐B2 (FcR) on macrophages is
the internalization of soluble antigen‐antibody complexes for lysosomal degradation. Most …

A latent infection membrane protein (LMP) encoded by the Epstein-Barr virus (EBV) genome
in latently infected, growth-transformed lymphocytes alters the phenotype of a human EBV …

When Chlamydomonas reinhardtii gametes of opposite mating type are mixed together, they
adhere by a flagella-mediated agglutination that triggers three rapid mating responses …