[HTML][HTML] Mechanisms and regulation of replication fork reversal
DNA replication is remarkably accurate with estimates of only a handful of mutations per
human genome per cell division cycle. Replication stress caused by DNA lesions …
human genome per cell division cycle. Replication stress caused by DNA lesions …
Control of DNA replication in vitro using a reversible replication barrier
EJ Vontalge, T Kavlashvili, SN Dahmen, MT Cranford… - Nature protocols, 2024 - nature.com
A major obstacle to studying DNA replication is that it involves asynchronous and highly
delocalized events. A reversible replication barrier overcomes this limitation and allows …
delocalized events. A reversible replication barrier overcomes this limitation and allows …
[HTML][HTML] BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
Tumor suppressor BRCA2 functions in homology-directed repair (HDR), the protection of
stalled replication forks, and the suppression of replicative gaps, but their relative …
stalled replication forks, and the suppression of replicative gaps, but their relative …
Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2
The BRCA2 tumour suppressor protein preserves genomic integrity via interactions with the
DNA-strand exchange RAD51 protein in homology-directed repair. The RAD51-binding TR2 …
DNA-strand exchange RAD51 protein in homology-directed repair. The RAD51-binding TR2 …
Poly (ADP-ribosyl) ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
J Rageul, N Lo, AL Phi, JA Patel, JJ Park, H Kim - Cell reports, 2024 - cell.com
Summary Poly (ADP-ribosyl) ation (PARylation), catalyzed mainly by poly (ADP-ribose)
polymerase (PARP) 1, is a key posttranslational modification involved in DNA replication …
polymerase (PARP) 1, is a key posttranslational modification involved in DNA replication …
Loo** out of control: R-loops in transcription-replication conflict
Transcription-replication conflict is a major cause of replication stress that arises when
replication forks collide with the transcription machinery. Replication fork stalling at sites of …
replication forks collide with the transcription machinery. Replication fork stalling at sites of …
Replication fork stalling in late S-phase elicits nascent strand degradation by DNA mismatch repair
E Colicino-Murbach, C Hathaway… - Nucleic Acids …, 2024 - academic.oup.com
Eukaryotic chromosomal replication occurs in a segmented, temporal manner wherein open
euchromatin and compact heterochromatin replicate during early and late S-phase …
euchromatin and compact heterochromatin replicate during early and late S-phase …
Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2–RAD51
H **e, L Song, G Mao, J Han, J Pu, Z Wu… - Nature Chemical …, 2025 - nature.com
The regressed arms of reversed replication forks exhibit structural similarities to one-ended
double-stranded breaks and need to be protected against uncontrolled nucleolytic …
double-stranded breaks and need to be protected against uncontrolled nucleolytic …
Disparate requirements for RAD54L in replication fork reversal
ME Uhrig, N Sharma, P Maxwell, J Gomez… - Nucleic acids …, 2024 - academic.oup.com
Abstract RAD54L is a DNA motor protein with multiple roles in homologous recombination
DNA repair. In vitro, RAD54L was shown to also catalyze the reversal and restoration of …
DNA repair. In vitro, RAD54L was shown to also catalyze the reversal and restoration of …
[HTML][HTML] RTEL1 and MCM10 overcome topological stress during vertebrate replication termination
Topological stress can cause converging replication forks to stall during termination of
vertebrate DNA synthesis. However, replication forks ultimately overcome fork stalling …
vertebrate DNA synthesis. However, replication forks ultimately overcome fork stalling …