Mitochondria are central hubs for energy production, metabolism and cellular signal
transduction in eukaryotic cells. Maintenance of mitochondrial homeostasis is important for …

Mitochondrial diseases encompass a heterogeneous group of disorders with a wide range
of clinical manifestations, most classically resulting in neurological, muscular, and metabolic …

Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from
rare, inborn errors of metabolism to common, age-associated diseases such as …

Although mitochondrial dysfunction is the known cause of primary mitochondrial disease,
mitochondrial dysfunction is often difficult to measure and prove, especially when biopsies of …

Mitochondria are small cellular constituents that generate cellular energy (ATP) by oxidative
phosphorylation (OXPHOS). Dysfunction of these organelles is linked to a heterogeneous …

Biomarker research in Parkinson's disease (PD) has long been dominated by measuring
dopamine metabolites or alpha-synuclein in cerebrospinal fluid. However, these markers do …

A decline in mitochondrial respiration represents the root cause of a large number of inborn
errors of metabolism. It is also associated with common age-associated diseases and the …

Objective: To directly compare the diagnostic utility of growth differentiation factor–15 (GDF-
15) with our previous fibroblast growth factor–21 (FGF-21) findings in the same adult …

Primary Pyruvate Dehydrogenase Complex Deficiency Overview - GeneReviews® - NCBI
Bookshelf US flag An official website of the United States government Here's how you know …

Mitochondrial disorders are a group of rare and heterogeneous genetic diseases
characterized by dysfunctional mitochondria leading to deficient adenosine triphosphate …