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Human surrogate models of central sensitization: A critical review and practical guide
Background As in other fields of medicine, development of new medications for
management of neuropathic pain has been difficult since preclinical rodent models do not …
management of neuropathic pain has been difficult since preclinical rodent models do not …
Cortical stimulation for chronic pain: from anecdote to evidence
Epidural stimulation of the motor cortex (eMCS) was devised in the 1990's, and has now
largely supplanted thalamic stimulation for neuropathic pain relief. Its mechanisms of action …
largely supplanted thalamic stimulation for neuropathic pain relief. Its mechanisms of action …
Neurotransmitters behind pain relief with transcranial magnetic stimulation–positron emission tomography evidence for release of endogenous opioids
Background Repetitive transcranial magnetic stimulation (rTMS) at M1/S1 cortex has been
shown to alleviate neuropathic pain. Objectives To investigate the possible neurobiological …
shown to alleviate neuropathic pain. Objectives To investigate the possible neurobiological …
Non-invasive motor cortex neuromodulation reduces secondary hyperalgesia and enhances activation of the descending pain modulatory network
Central sensitization is a driving mechanism in many chronic pain patients, and manifests as
hyperalgesia and allodynia beyond any apparent injury. Recent studies have demonstrated …
hyperalgesia and allodynia beyond any apparent injury. Recent studies have demonstrated …
Clinical neurophysiology of pain
JP Lefaucheur - Handbook of Clinical Neurology, 2019 - Elsevier
Clinical neurophysiologic investigation of pain pathways in humans is based on specific
techniques and approaches, since conventional methods of nerve conduction studies and …
techniques and approaches, since conventional methods of nerve conduction studies and …
Analgesic effects of high-frequency rTMS on pain anticipation and perception
Previous studies suggest that pain perception is greatly shaped by anticipation, with M1 and
DLPFC involved in this process. We hypothesized that high-frequency rTMS targeting these …
DLPFC involved in this process. We hypothesized that high-frequency rTMS targeting these …
Motor cortex stimulation for pain: a narrative review of indications, techniques, and outcomes
Background Motor cortex stimulation (MCS) was introduced in 1985 and has been tested
extensively for different types of peripheral and central neuropathic pain syndromes (eg …
extensively for different types of peripheral and central neuropathic pain syndromes (eg …
Anodal transcranial direct current stimulation over the primary motor cortex attenuates capsaicin‐induced dynamic mechanical allodynia and mechanical pain …
Background Anodal transcranial direct current stimulation over the primary cortex has been
shown to activate regions of the brain involved in the descending modulation of pain …
shown to activate regions of the brain involved in the descending modulation of pain …
Effects of multifocal transcranial direct current stimulation targeting the motor network during prolonged experimental pain
Background Antinociceptive effects of transcranial direct current stimulation (tDCS) over the
primary motor cortex (M1) have been extensively studied in the past years. However, M1 …
primary motor cortex (M1) have been extensively studied in the past years. However, M1 …
[HTML][HTML] Multifocal tDCS targeting the motor network modulates event-related cortical responses during prolonged pain
Multifocal transcranial direct current stimulation (tDCS) targeting several brain regions is
promising for inducing cortical plasticity. It remains unknown whether multifocal tDCS aimed …
promising for inducing cortical plasticity. It remains unknown whether multifocal tDCS aimed …