The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Background: Breast Cancer (BC) is the second most common cause of cancer related
deaths in women. Due to severe side effects and multidrug resistance, current therapies like …

Ursolic acid (UA), which has many biological properties such as anti-cancer, anti-
inflammatory and antioxidant, and regulates some pharmacological processes, has been …

A new thiosemicarbazide-based Schiff base (TSDHB) was synthesized from
thiosemicarbazide and 2, 3-dihydroxybenzaldehyde. The prepared thiosemicarbazone was …

Abstract Vascular Endothelial Growth Factor II (VEGFR-2) has been proved as a rational
target in cancer therapy. Although currently prescribed VEGFR-2 inhibitors are showing …

Background: Cancer accounts for several deaths each year. There are multiple FDA
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …

In this study, we report the synthesis and structural characterization of a series of
thiosemicarbazone and 4-thiazolidinones derivatives, as well as their in vitro antiproliferative …

A simple approach to synthesize new highly substituted 4 H-pyran derivatives is described.
Efficient Et3N acts as a readily accessible catalyst of this process performed in pure water …

Dapoxetine is a selective serotonin reuptake inhibitor, used to treat premature ejaculation in
men. Dapoxetine may interact with theDNAand hence this study investigated dapoxetine …

In this study, we report the synthesis of eight novel indole-thiazole and indole-thiazolidinone
derivatives, as well as their ability to interact with DNA, analysed through the UV–vis …