Double-stranded RNA (dsRNA) is associated with most viral infections—it either constitutes
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …

Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …

Summary G3BP1/2 are paralogous proteins that promote stress granule formation in
response to cellular stresses, including viral infection. The nucleocapsid (N) protein of …

Considerable progress has been made in understanding the molecular host-virus battlefield
during SARS-CoV-2 infection. Nevertheless, the assembly and egress of newly formed …

Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism
within cells, facilitating the formation of distinct compartments, including membraneless …

Alu elements are highly abundant primate-specific short interspersed nuclear elements that
account for~ 10% of the human genome. Due to their preferential location in gene-rich …

RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune
responses and have immense physiological importance. In this review, we first summarize …

Emerging data suggest that induction of viral mimicry responses through activation of double-
stranded RNA (dsRNA) sensors in cancer cells is a promising therapeutic strategy. One …

Biomolecular condensates are membraneless organelles formed through liquid–liquid
phase separation. Innate immunity is essential to host defense against infections, but …

The presence of foreign nucleic acids in the cytosol is a marker of infection. Cells have
sensors, also known as pattern recognition receptors (PRRs), in the cytosol that detect …