Notochordal cell-based treatment strategies and their potential in intervertebral disc regeneration
FC Bach, DW Poramba-Liyanage… - Frontiers in Cell and …, 2022 - frontiersin.org
Chronic low back pain is the number one cause of years lived with disability. In about 40% of
patients, chronic lower back pain is related to intervertebral disc (IVD) degeneration. The …
patients, chronic lower back pain is related to intervertebral disc (IVD) degeneration. The …
Importance of matrix cues on intervertebral disc development, degeneration, and regeneration
Back pain is one of the leading causes of disability worldwide and is frequently caused by
degeneration of the intervertebral discs. The discs' development, homeostasis, and …
degeneration of the intervertebral discs. The discs' development, homeostasis, and …
Biglycan: an emerging small leucine-rich proteoglycan (SLRP) marker and its clinicopathological significance
Extracellular matrix (ECM) plays an important role in the structural organization of tissue and
delivery of external cues to the cell. Biglycan, a class I small leucine-rich proteoglycans …
delivery of external cues to the cell. Biglycan, a class I small leucine-rich proteoglycans …
BMSC‐Derived Exosomes Alleviate Intervertebral Disc Degeneration by Modulating AKT/mTOR‐Mediated Autophagy of Nucleus Pulposus Cells
Q **ao, Z Zhao, Y Teng, L Wu, J Wang… - Stem cells …, 2022 - Wiley Online Library
The pathogenesis of intervertebral disc degeneration (IDD) is still unclear. It has been
shown that the pathological process of IDD is most closely related to inflammation of nucleus …
shown that the pathological process of IDD is most closely related to inflammation of nucleus …
Development, pathogenesis, and regeneration of the intervertebral disc: current and future insights spanning traditional to omics methods
TT Hickman, S Rathan-Kumar, SH Peck - Frontiers in Cell and …, 2022 - frontiersin.org
The intervertebral disc (IVD) is the fibrocartilaginous joint located between each vertebral
body that confers flexibility and weight bearing capabilities to the spine. The IVD plays an …
body that confers flexibility and weight bearing capabilities to the spine. The IVD plays an …
Current perspectives on nucleus pulposus fibrosis in disc degeneration and repair
A growing body of evidence in humans and animal models indicates an association
between intervertebral disc degeneration (IDD) and increased fibrotic elements in the …
between intervertebral disc degeneration (IDD) and increased fibrotic elements in the …
Multiphoton microfabrication and micropatternining (MMM)-based screening of multiplex cell niche factors for phenotype maintenance-Bovine nucleus pulposus cell …
Upon monolayer cultures on flat and rigid plastic dishes, many cells de-differentiate and lose
their native phenotype. Technologies able to identify and reconstitute the cell niche factors …
their native phenotype. Technologies able to identify and reconstitute the cell niche factors …
Development of a Perfusion Bioreactor for the Fabrication and Optimization of Bioengineered Intervertebral Discs
AJS Upenieks - 2022 - search.proquest.com
A therapeutic approach to treating the degeneration of the intervertebral disc (IVD) would
involve the tissue engineering of a biological disc replacement using a perfusion bioreactor …
involve the tissue engineering of a biological disc replacement using a perfusion bioreactor …
Comparison of Injection Saline and External Fixator in Rat Tail's Disc Degeneration
MA Khaleque, EY Choi, SE Park, HY You, WJ Lee… - 2023 - preprints.org
Purpose: The intervertebral disc is a leading avascular organ in the body that may gather
nutrition through diffusion. It maintains homeostasis by the use of autophagy and apoptosis …
nutrition through diffusion. It maintains homeostasis by the use of autophagy and apoptosis …