Air pollution and the airways: lessons from a century of human urbanization

J Goossens, AC Jonckheere, LJ Dupont, DMA Bullens - Atmosphere, 2021 - mdpi.com
Since the industrial revolution, air pollution has become a major problem causing several
health problems involving the airways as well as the cardiovascular, reproductive, or …

Impact of obesity in asthma: Possible future therapies

H Tashiro, Y Kurihara, Y Kuwahara… - Allergology …, 2024 - jstage.jst.go.jp
abstract Obesity is one of the factors associated with the severity of asthma. Obesity is
associated with aggravation of the pathophysiology of asthma, including exacerbations …

Sex differences in pulmonary eicosanoids and specialized pro-resolving mediators in response to ozone exposure

MJ Yaeger, SW Reece, B Kilburg-Basnyat… - Toxicological …, 2021 - academic.oup.com
Ozone (O3) is a criteria air pollutant known to increase the morbidity and mortality of
cardiopulmonary diseases. This occurs through a pulmonary inflammatory response …

Ozone exposure promotes pyroptosis in rat lungs via the TLR2/4-NF-κB-NLRP3 signaling pathway

L Tian, J Yan, K Li, W Zhang, B Lin, W Lai, L Bian, H Liu… - Toxicology, 2021 - Elsevier
Objective Ozone has become a major air pollutant in recent years, which leading to a variety
of lung diseases. This study aimed to explore the mechanisms of pyroptosis and related …

[HTML][HTML] Role of NLRP3 in the exacerbation of ozone-induced allergic rhinitis

X Zhang, N Sun, Y Huang, Y Duan, R Zhang - … and Environmental Safety, 2023 - Elsevier
Objective Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory disorder
of the nasal mucosa, and the impact of ozone on AR is gaining increasing attention …

Altered ontogeny and transcriptomic signatures of tissue-resident pulmonary interstitial macrophages ameliorate allergic airway hyperresponsiveness

RM Tighe, A Birukova, Y Malakhau… - Frontiers in …, 2024 - frontiersin.org
Introduction Environmental exposures and experimental manipulations can alter the
ontogenetic composition of tissue-resident macrophages. However, the impact of these …

Alteration of glycosphingolipid metabolism by ozone is associated with exacerbation of allergic asthma characteristics in mice

NC Stevens, VJ Brown, MC Domanico… - Toxicological …, 2023 - academic.oup.com
Asthma is a common chronic respiratory disease exacerbated by multiple environmental
factors. Acute ozone exposure has previously been implicated in airway inflammation …

Neuroendocrine contribution to sex-related variations in adverse air pollution health effects

DI Alewel, UP Kodavanti - Journal of Toxicology and …, 2024 - Taylor & Francis
Air pollution exposure is ranked as a leading environmental risk factor for not only
cardiopulmonary diseases but also for systemic health ailments including diabetes …

Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease

I Choudhary, T Vo, K Paudel, X Wen, R Gupta… - Scientific reports, 2021 - nature.com
Lung epithelial lining fluid (ELF) harbors a variety of proteins that influence homeostatic and
stress responses in the airspaces. Exosomes, nano-sized extracellular vesicles, contain …

[HTML][HTML] Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung

CBM Tulen, SJ Snow, PA Leermakers, UP Kodavanti… - Toxicology, 2022 - Elsevier
Exposure of the airways to cigarette smoke (CS) is the primary risk factor for develo**
several lung diseases such as Chronic Obstructive Pulmonary Disease (COPD). CS consists …