The success of the messenger RNA-based COVID-19 vaccines of Moderna and
Pfizer/BioNTech marks the beginning of a new chapter in modern medicine. However, the …

From a clinical perspective, local anesthetics have rather widespread application in regional
blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer …

CRISPR/Cas9 systems have great potential to achieve sophisticated gene therapy and cell
engineering by editing multiple genomic loci. However, to achieve efficient multiplex gene …

Lipid nanoparticles (LNPs) employing ionizable lipids are the most advanced technology for
delivery of RNA, most notably mRNA, to cells. LNPs represent well-defined core–shell …

Co-delivery of different protein-encoding polynucleotide species with varying expression
kinetics of their therapeutic product will become a prominent requirement in the realm of …

Abstract The messenger RNA (mRNA) SARS-CoV-2 vaccines have demonstrated the
therapeutic potential of this novel drug modality. Protein expression is the consequence of a …

Abstract COVID-19, caused by SARS-CoV-2, is a positive-strand RNA belonging to
Coronaviridae family, along with MERS and SARS. Since its first report in 2019 in Wuhan …

Immunotherapy has demonstrated great clinical success in the field of oncology in
comparison with conventional cancer therapy. However, cancer immunotherapy still …

Alphaviruses are globally distributed, vector-borne RNA viruses with high outbreak potential
and no clinical interventions, posing a significant global health threat. Previously, the …

Nanocarriers are transport and encapsulation systems that primarily serve to protect and
improve the dispersibility of predominantly hydrophobic active ingredients but also enable …