Insulin resistance and Parkinson's disease: a new target for disease modification?

D Athauda, T Foltynie - Progress in neurobiology, 2016‏ - Elsevier
There is growing evidence that patients with Type 2 diabetes have an increased risk of
develo** Parkinson's disease and share similar dysregulated pathways suggesting …

Insulin resistance in Alzheimer's disease

LSS Ferreira, CS Fernandes, MNN Vieira… - Frontiers in …, 2018‏ - frontiersin.org
The epidemiological connection between diabetes, obesity, and dementia represents an
important public health challenge but also an opportunity to further understand these …

Diabetes mellitus in elderly

F Chentli, S Azzoug, S Mahgoun - Indian journal of endocrinology …, 2015‏ - journals.lww.com
Diabetes mellitus (DM) frequency is a growing problem worldwide, because of long life
expectancy and life style modifications. In old age (≥ 60–65 years old), DM is becoming an …

[HTML][HTML] Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain

DA Butterfield, F Di Domenico, E Barone - Biochimica et Biophysica Acta …, 2014‏ - Elsevier
Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological data show that …

The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer's disease

H Du, X Meng, Y Yao, J Xu - Frontiers in Endocrinology, 2022‏ - frontiersin.org
Since type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease (AD) and both
have the same pathogenesis (eg, insulin resistance), drugs used to treat T2DM have been …

Oxidative and nitrative stress in neurodegeneration

CA Cobb, MP Cole - Neurobiology of disease, 2015‏ - Elsevier
Aerobes require oxygen for metabolism and normal free radical formation. As a result,
maintaining the redox homeostasis is essential for brain cell survival due to their high …

The role of type 2 diabetes in neurodegeneration

G Verdile, SJ Fuller, RN Martins - Neurobiology of disease, 2015‏ - Elsevier
A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …

Role of diet and nutritional supplements in Parkinson's disease progression

LK Mischley, RC Lau… - Oxidative medicine and …, 2017‏ - Wiley Online Library
Objectives. The goal of this study is to describe modifiable lifestyle variables associated with
reduced rate of Parkinson's disease (PD) progression. Methods. The patient‐reported …

Type 2 diabetes mellitus as a risk factor for Alzheimer's disease: Review and meta-analysis

A Athanasaki, K Melanis, I Tsantzali, MI Stefanou… - Biomedicines, 2022‏ - mdpi.com
Alzheimer's disease is the most common type of dementia, reaching 60–80% of case totals,
and is one of the major global causes of the elderly population's decline in functionality …

Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies

BJ Dutta, S Singh, S Seksaria, GD Gupta… - Pharmacological …, 2022‏ - Elsevier
Type 2 diabetes mellitus (T2DM) the most prevalent metabolic disease that has evolved into
a major public health issue. Concerning about its secondary complications, a growing body …