The Pharmacological Activities of Crocus sativus L.: A Review Based on the Mechanisms and Therapeutic Opportunities of its Phytoconstituents

M Butnariu, C Quispe, J Herrera-Bravo… - Oxidative medicine …, 2022 - Wiley Online Library
Crocus species are mainly distributed in North Africa, Southern and Central Europe, and
Western Asia, used in gardens and parks as ornamental plants, while Crocus sativus …

[HTML][HTML] A comprehensive review of cardiovascular disease management: cardiac biomarkers, imaging modalities, pharmacotherapy, surgical interventions, and …

VR Netala, SK Teertam, H Li, Z Zhang - Cells, 2024 - mdpi.com
Cardiovascular diseases (CVDs) continue to be a major global health concern, representing
a leading cause of morbidity and mortality. This review provides a comprehensive …

Protective effects of crocin on testicular torsion/detorsion in rats

V Ganjiani, N Ahmadi, MR Divar, H Sharifiyazdi… - Theriogenology, 2021 - Elsevier
Oxidative stress, caused by extreme accumulation of un-scavenged reactive oxygen
species, plays an integral role in the Ischemia-Reperfusion (I/R) injury to the testicles …

Treatment with crocin improves cardiac dysfunction by normalizing autophagy and inhibiting apoptosis in STZ-induced diabetic cardiomyopathy

K Feidantsis, K Mellidis, E Galatou, Z Sinakos… - Nutrition, Metabolism …, 2018 - Elsevier
Background and aim The association of diabetes mellitus (DM) and poor metabolic control
with high incidence of cardiovascular diseases is well established. The aim of this study was …

The effect of saffron supplementation on some inflammatory and oxidative markers, leptin, adiponectin, and body composition in patients with nonalcoholic fatty liver …

F Kavianipour, N Aryaeian, M Mokhtare… - Phytotherapy …, 2020 - Wiley Online Library
Background Nonalcoholic fatty liver disease (NAFLD) is characterized by oxidative stress
and inflammation in the hepatocytes. Saffron and its constituents are reported to have …

The beneficial effects of saffron extract on potential oxidative stress in cardiovascular diseases

X Su, C Yuan, L Wang, R Chen, X Li… - Oxidative medicine …, 2021 - Wiley Online Library
Saffron is commonly used in traditional medicines and precious perfumes. It contains
pharmacologically active compounds with notably potent antioxidant activity. Saffron has a …

Crocin attenuates inflammation of lung tissue in ovalbumin‐sensitized mice by altering the expression of endoplasmic reticulum stress markers

MR Aslani, M Amani, N Masrori, MH Boskabady… - Biofactors, 2022 - Wiley Online Library
Endoplasmic reticulum (ER) stress plays a pivotal role in the pathogenesis of asthma. The
present study aimed to investigate the reducing or suppressing effects of crocin in ovalbumin …

[HTML][HTML] Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms

A Mokhtari-Zaer, MR Khazdair… - Avicenna journal of …, 2015 - ncbi.nlm.nih.gov
Abstract Saffron, Crocus sativus L.(C. sativus) is rich in carotenoids and used in traditional
medicine for treatment of various conditions such as coughs, stomach disorders …

The cardiovascular‐protective properties of saffron and its potential pharmaceutical applications: A critical appraisal of the literature

NPE Kadoglou, E Christodoulou… - Phytotherapy …, 2021 - Wiley Online Library
Saffron, the dried stigma of Crocus sativus L., is used in traditional medicine for its healing
properties and the treatment of various pathological conditions. The present literature review …

Evaluation of modulatory effects of saffron (Crocus sativus L.) aqueous extract on oxidative stress in ischemic stroke patients: a randomized clinical trial

S Gudarzi, M Jafari, G Pirzad Jahromi… - Nutritional …, 2022 - Taylor & Francis
ABSTRACT Objectives Saffron (Crocus sativus L.) has been widely used in traditional
medicine as a treatment of nervous disorders. Saffron as an antioxidant can be considered …