Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Recent advances in understanding the role of mitochondrial dysfunction in
neurodegenerative diseases have expanded the opportunities for neurotherapeutics …

Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …

Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …

Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by
progressive loss of neuronal functions and structures. Despite having different genetic …

Curcumin, the dietary polyphenol isolated from Curcuma longa (turmeric), is commonly used
as an herb and spice worldwide. Because of its bio-pharmacological effects curcumin is also …

Regular exercise is associated with pronounced health benefits. The molecular processes
involved in physiological adaptations to exercise are best understood in skeletal muscle …