Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

As people age, iron deposits in different areas of the brain may impair normal cognitive
function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the …

Background Dementia is common in Parkinson's disease (PD) but measures that track
cognitive change in PD are lacking. Brain tissue iron accumulates with age and co-localises …

Beta amyloid is a protein fragment snipped from the amyloid precursor protein (APP).
Aggregation of these peptides into amyloid plaques is one of the hallmarks of Alzheimer's …

The complexity of Alzheimer's disease (AD) complicates the search for effective treatments.
While the key roles of pathologically modified proteins has occupied a central role in …

The neocortex of the human brain is the seat of higher brain function. Modern imaging
techniques, chief among them magnetic resonance imaging (MRI), allow non-invasive …

Alzheimer's disease (AD) is the most common type of dementia and a distressing diagnosis
for individuals and caregivers. Researchers and clinical trials have mainly focused on β …

Alzheimer's disease (AD) is a debilitating brain disorder that afflicts millions worldwide with
no effective treatment. Currently, AD progression has primarily been characterized by …

Quantitative susceptibility map** (QSM) is a physics-driven computational technique that
has a high sensitivity in quantifying iron deposition based on MRI phase images …

Quantitative susceptibility map** (QSM) has gained broad interest in the field by extracting
bulk tissue magnetic susceptibility, predominantly determined by myelin, iron and calcium …