As the most voluminous organ of the body that is exposed to the outer environment, the skin
suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features …

Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

World population has been continuously increasing and progressively aging. Aging is
characterized by a complex and intraindividual process associated with nine major cellular …

The biological effects of the bisphosphonates (BPs) as inhibitors of calcification and bone
resorption were first described in the late 1960s. In the 50 years that have elapsed since …

Cellular senescence was formally described more than 40 years ago as a process that
limited the proliferation (growth) of normal human cells in culture (Hayflick, 1965). This …

Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-co** resilience to cells, contribute to subcellular and tissue-specific …

The first full publications on the biological effects of the diphosphonates, later renamed
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …