Alterations to the cerebral microcirculation have been recognized to play a crucial role in the
development of neurodegenerative disorders. However, the exact role of the microvascular …

Background Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a
promising technique to characterize pathology and evaluate treatment response. However …

Objectives Glioblastoma multiforme (GBM), the most aggressive glial brain tumors, can
metabolize glucose through glycolysis and mitochondrial oxidation pathways. While specific …

Abstract The Brain Imaging Data Structure (BIDS) established community consensus on the
organization of data and metadata for several neuroimaging modalities. Traditionally, BIDS …

Nicotinic acetylcholine α7 receptors (α7 nAChRs) have a well-known modulator effect in
neuroinflammation. Yet, the therapeutical effect of α7 nAChRs activation after stroke has …

Simultaneously being a nonradiative and noninvasive technique makes magnetic
resonance imaging (MRI) one of the highly required imaging approaches for the early …

Glioblastoma (GBM) is the most common primary malignant brain tumor. Currently, there are
few effective treatment options for GBM beyond surgery and chemo-radiation, and even with …

Transcranial application of focused ultrasound (FUS) combined with vascular introduction of
microbubble contrast agents (MBs) has emerged as a non-invasive technique that can …

In dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) a sequence of MRI
images are acquired to measure the passage of a contrast-agent within a tissue of interest …

Background Many medical imaging techniques utilize fitting approaches for quantitative
parameter estimation and analysis. Common examples are pharmacokinetic modeling in …