The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

Protein ubiquitination is a posttranslational modification that plays an integral part in
mediating diverse cellular functions. The process of protein ubiquitination requires an …

Mammalian excitatory synapses express diverse types of synaptic plasticity. A major
challenge in neuroscience is to understand how a neuron utilizes different types of plasticity …

Neurons are characterized by a complex morphology that enables the generation of
subcellular compartments with unique biochemical and biophysical properties, such as …

Ubiquitination is a fundamental post-translational modification that regulates almost all
aspects of cellular signalling and is ultimately catalysed by the action of E3 ubiquitin ligases …

Neuronal activity regulates the transcription and translation of the immediate-early gene
Arc/Arg3. 1, a key mediator of synaptic plasticity. Proteasome-dependent degradation of Arc …

Activity-dependent changes in neuronal function require coordinated regulation of the
protein synthesis and protein degradation machinery to maintain protein homeostasis …

The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …

p38 is a mitogen-activated protein kinase (MAPK), that responds primarily to stress stimuli.
p38 has a number of targets for phosphorylation, including MAPK-activated protein kinase 2 …

Classical studies have shown that neuronal immediate-early genes (IEGs) play important
roles in synaptic processes critical for key brain functions. IEGs are transiently activated and …