Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts
X Ding, LS Kaminsky - Annual review of pharmacology and …, 2003 - annualreviews.org
Cytochrome P450 (CYP) enzymes in extrahepatic tissues often play a dominant role in
target tissue metabolic activation of xenobiotic compounds. They may also determine drug …
target tissue metabolic activation of xenobiotic compounds. They may also determine drug …
Genetic Polymorphism of CYP Genes, Alone or in Combination, as a Risk Modifier of Tobacco-related Cancers
H Bartsch, U Nair, A Risch, M Rojas, H Wikman… - … Biomarkers & Prevention, 2000 - AACR
Tobacco use is causally associated with cancers of the lung, larynx, mouth, esophagus,
kidneys, urinary tract, and possibly, breast. Major classes of carcinogens present in tobacco …
kidneys, urinary tract, and possibly, breast. Major classes of carcinogens present in tobacco …
Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung
J Hukkanen, O Pelkonen, J Hakkola… - Critical reviews in …, 2002 - Taylor & Francis
Pathogenesis of lung diseases, such as lung cancer and chronic obstructive pulmonary
disease, is tightly linked to exposure to environmental chemicals, most notably tobacco …
disease, is tightly linked to exposure to environmental chemicals, most notably tobacco …
Tissue distribution of MRNA expression of human cytochrome P450 isoforms assessedby high-sensitivity real-time reverse transcription PCR
M Nishimura, H Yaguti, H Yoshitsugu, S Naito… - Yakugaku …, 2003 - jstage.jst.go.jp
Pairs of forward and reverse primers and TaqMan probes specific to each human
cytochrome P450 isoform were prepared. Analysis of the mRNA level of each CYP isoform …
cytochrome P450 isoform were prepared. Analysis of the mRNA level of each CYP isoform …
Pulmonary drug metabolism, clearance, and absorption
B Olsson, E Bondesson, L Borgström… - … pulmonary drug delivery, 2011 - Springer
Delivering therapeutic agents to the lungs requires a deep understanding of the kinetics and
dynamics of drugs in this biologically and physiologically complex system. In this chapter …
dynamics of drugs in this biologically and physiologically complex system. In this chapter …
Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach
JV Castell, MT Donato, MJ Gómez-Lechón - Experimental and Toxicologic …, 2005 - Elsevier
Lung is a target organ for the toxicity of inhalated compounds. The respiratory tract is
frequently exposed to elevated concentrations of these compounds and become the primary …
frequently exposed to elevated concentrations of these compounds and become the primary …
In utero tobacco exposure epigenetically modifies placental CYP1A1 expression
M Suter, A Abramovici, L Showalter, M Hu, C Do Shope… - Metabolism, 2010 - Elsevier
The metabolic pathways used by higher-eukaryotic organisms to deal with potentially
carcinogenic xenobiotic compounds from tobacco smoke have been well characterized …
carcinogenic xenobiotic compounds from tobacco smoke have been well characterized …
Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models
F Oesch, E Fabian, R Landsiedel - Archives of toxicology, 2019 - Springer
The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the
organism, is crucial for inhaled compounds entering this organ intentionally (eg drugs) and …
organism, is crucial for inhaled compounds entering this organ intentionally (eg drugs) and …
The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition
Significant intra-and interindividual variability has been observed in response to use of
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by …
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by …
[HTML][HTML] Maximizing the relevance and reproducibility of A549 cell culture using FBS-free media
Scientists are using in vitro methods to answer important research questions and
implementing strategies to maximize the reliability and human relevance of these methods …
implementing strategies to maximize the reliability and human relevance of these methods …