New perspectives in diabetic neuropathy
Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …
Clinical Pathobiochemistry of Vitamin B12 Deficiency: Improving Our Understanding by Exploring Novel Mechanisms with a Focus on Diabetic Neuropathy
E Schleicher, T Didangelos, E Kotzakioulafi, A Cegan… - Nutrients, 2023 - mdpi.com
Vitamin B12 (B12) is an essential cofactor of two important biochemical pathways, the
degradation of methylmalonic acid and the synthesis of methionine from homocysteine …
degradation of methylmalonic acid and the synthesis of methionine from homocysteine …
Metabolic memory: mechanisms and diseases
H Dong, Y Sun, L Nie, A Cui, P Zhao… - Signal transduction and …, 2024 - nature.com
Metabolic diseases and their complications impose health and economic burdens
worldwide. Evidence from past experimental studies and clinical trials suggests our body …
worldwide. Evidence from past experimental studies and clinical trials suggests our body …
Genetic and epigenomic modifiers of diabetic neuropathy
M Jankovic, I Novakovic, D Nikolic… - International journal of …, 2021 - mdpi.com
Diabetic neuropathy (DN), the most common chronic and progressive complication of
diabetes mellitus (DM), strongly affects patients' quality of life. DN could be present as …
diabetes mellitus (DM), strongly affects patients' quality of life. DN could be present as …
TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 …
X Zhang, S Zhao, Q Yuan, L Zhu, F Li, H Wang… - Cell death & …, 2021 - nature.com
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus
(DM) and the dysfunction of Schwann cells plays an important role in the pathogenesis of …
(DM) and the dysfunction of Schwann cells plays an important role in the pathogenesis of …
Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy
E Bäckryd, A Themistocleous, A Larsson, T Gordh… - Scientific Reports, 2024 - nature.com
About 20% of patients with diabetes suffer from chronic pain with neuropathic
characteristics. We investigated the multivariate associations between 92 neurology-related …
characteristics. We investigated the multivariate associations between 92 neurology-related …
Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth
Y Liu, M Tian, Y Yang, H Li, T Zhao, J Zhu, F Mou… - Iscience, 2022 - cell.com
As a common complication of diabetes, the pathogenesis of diabetic peripheral neuropathy
(DPN) is closely related to high glucose but has not been clarified. Exosomes can mediate …
(DPN) is closely related to high glucose but has not been clarified. Exosomes can mediate …
[HTML][HTML] Multi-omics integration strategies for animal epigenetic studies—A review
DY Kim, JM Kim - Animal bioscience, 2021 - ncbi.nlm.nih.gov
Genome-wide studies provide considerable insights into the genetic background of animals;
however, the inheritance of several heritable factors cannot be elucidated. Epigenetics …
however, the inheritance of several heritable factors cannot be elucidated. Epigenetics …
Differentially methylated and expressed genes in familial type 1 diabetes
There has recently been a growing interest in examining the role of epigenetic modifications,
such as DNA methylation, in the etiology of type 1 diabetes (T1D). This study aimed to …
such as DNA methylation, in the etiology of type 1 diabetes (T1D). This study aimed to …
[HTML][HTML] Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: predictors of pathology and RAS blockade effects
SA Eid, LM Hinder, H Zhang, R Eksi, V Nair… - … : official publication of …, 2021 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN) are two common
diabetic complications. However, their pathogenesis remains elusive and current therapies …
diabetic complications. However, their pathogenesis remains elusive and current therapies …