Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and
heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to …

The pathogenesis of hypertension is known to involve a diverse range of contributing factors
including genetic, environmental, hormonal, hemodynamic and inflammatory forces, to …

For more than 50 years, evidence has accumulated that inflammation contributes to the
pathogenesis of hypertension. Immune cells have been observed in vessels and kidneys of …

High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

Background: Salt sensitivity of blood pressure is an independent predictor of cardiovascular
morbidity and mortality. The exact mechanism by which salt intake increases blood pressure …

Sodium accumulates in the interstitium and promotes inflammation through poorly defined
mechanisms. We describe a pathway by which sodium enters dendritic cells (DCs) through …

A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular
disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells …