Although enhancers are crucial and widespread gene-regulatory elements, we are far from
a complete understanding of how they function or their importance in areas such as disease …

Diabetes mellitus is a lifelong, metabolic disease that is characterised by an inability to
maintain normal glucose homeostasis. There are several different forms of diabetes …

The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in
gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically …

The mechanism by which mammalian liver cell responses are coordinated during tissue
homeostasis and perturbation is poorly understood, representing a major obstacle in our …

Type 2 diabetes (T2D) is the result of interaction between environmental factors and a strong
hereditary component. We review the heritability of T2D as well as the history of genetic and …

Type 2 diabetes (T2D) is characterized by insulin resistance and increased hepatic glucose
production, yet the molecular mechanisms underlying these abnormalities are poorly …

Abstract Tribbles pseudokinase 3 (TRIB3) has been identified recently as a novel oncogene
in several cancers. Still, further extensive research is imperative to elucidate its function and …

Sclerostin has traditionally been thought of as a local inhibitor of bone acquisition that
antagonizes the profound osteoanabolic capacity of activated Wnt/β-catenin signaling, but …

Understanding the regulation of islet cell mass has important implications for the discovery
of regenerative therapies for diabetes. The liver plays a central role in metabolism and the …

Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to
regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that …