Biosynthesis of citrus flavonoids and their health effects

C Zhao, F Wang, Y Lian, H **ao… - Critical reviews in food …, 2020 - Taylor & Francis
Citrus-derived flavonoids play important roles in the regulation of physiological conditions of
citrus plants, including color changes of flower and fruit, flavor development, and anti-stress …

Phytochemistry and bioactivity of Citrus flavonoids: a focus on antioxidant, anti-inflammatory, anticancer and cardiovascular protection activities

L Yi, S Ma, D Ren - Phytochemistry Reviews, 2017 - Springer
Epidemiological studies have suggested an inverse relationship between increased
consumption of fruits and reduced risk of chronic diseases, such as cardiovascular diseases …

Dietary tangeretin alleviated dextran sulfate sodium-induced colitis in mice via inhibiting inflammatory response, restoring intestinal barrier function, and modulating …

B Chen, J Luo, Y Han, H Du, J Liu, W He… - Journal of Agricultural …, 2021 - ACS Publications
In this study, the preventive effect of tangeretin (TAN), a natural flavonoid derivative from
citrus fruits, on the dextran sulfate sodium (DSS)-induced colitis in mice was evaluated. Our …

Anticancer Activity of Novel Plant Extracts and Compounds from Adenosma bracteosum (Bonati) in Human Lung and Liver Cancer Cells

NH Nguyen, QTH Ta, QT Pham, TNH Luong, VT Phung… - Molecules, 2020 - mdpi.com
Cancer is the second leading cause of death globally, and despite the advances in drug
development, it is still necessary to develop new plant-derived medicines. Compared with …

The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro

H Huang, L Li, W Shi, H Liu, J Yang… - Evidence‐Based …, 2016 - Wiley Online Library
Nobiletin (NOB) chemically known as 5, 6, 7, 8, 3′, 4′‐hexamethoxyflavone is a dietary
polymethoxylated flavonoid found in Citrus fruits. Recent evidences show that NOB is a …

Fast Separation and Sensitive Quantitation of Polymethoxylated Flavonoids in the Peels of Citrus Using UPLC-Q-TOF-MS

TT **ng, XJ Zhao, YD Zhang, YF Li - Journal of Agricultural and …, 2017 - ACS Publications
A rapid, sensitive, and efficient ultraperformance liquid chromatography coupled with
quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) method has been …

Nobiletin as a chemopreventive natural product against cancer, a comprehensive review

YY Chen, JJ Liang, DL Wang, JB Chen… - Critical Reviews in …, 2023 - Taylor & Francis
As a leading cause of death, second only to heart disease, cancer has always been one of
the burning topics in medical research. When targeting multiple signal pathways in …

Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell …

X Wu, M Song, Z Gao, Y Sun, M Wang, F Li… - The Journal of nutritional …, 2017 - Elsevier
Nobiletin (NOB) is a major citrus polymethoxyflavone (PMF) with various beneficial
biological activities. We reported previously that dietary NOB significantly inhibited colitis …

In-vivo biotransformation of citrus functional components and their effects on health

A Karn, C Zhao, F Yang, J Cui, Z Gao… - Critical Reviews in …, 2021 - Taylor & Francis
Citrus, one of the most popular fruits worldwide, contains various functional components,
including flavonoids, dietary fibers (DFs), essential oils (EOs), synephrines, limonoids, and …

A metabolite of nobiletin, 4′-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and …

X Wu, M Song, P Qiu, F Li, M Wang, J Zheng… - Food & function, 2018 - pubs.rsc.org
Combining different chemopreventive agents is a promising strategy to reduce cancer
incidence and mortality due to potential synergistic interactions between these agents …