Abstract The C–X–C motif ligand 16, or CXCL16, is a chemokine that belongs to the ELR−
CXC subfamily. Its function is to bind to the chemokine receptor CXCR6, which is a G protein …

Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unknown origin
characterized by progressive scarring of the lung leading to irreversible loss of function …

Obeticholic acid (OCA) has been examined to treat non-alcoholic steatohepatitis (NASH),
but has unsatisfactory antifibrotic effect and deficient responsive rate in recent phase III …

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and shows
high global incidence and mortality rates. The liver is an immune-tolerated organ with a …

Background Liver cirrhosis is commonly accompanied by intestinal dysbiosis and metabolic
defects. Many clinical trials have shown microbiota-targeting strategies represent promising …

Background Hepatic fibrosis is a pathophysiological process of extracellular matrix
abnormal deposition induced by multiple pathogenic factors. Currently, there is still a lack of …

Lymphedema is a debilitating disease characterized by extremity edema, fibroadipose
deposition, impaired lymphangiogenesis, and dysfunctional lymphatics, often with lymphatic …

Abstract Background and Aims: Liver fibrosis is the common pathological pathway of chronic
liver diseases and its mechanisms of which have not been fully declared. Macrophages play …

Chronic liver diseases, primarily metabolic dysfunction-associated steatotic liver disease
(MASLD), metabolic and metabolic dysfunction-associated alcoholic liver disease (MetALD) …

Multiple immune cells and their products in the liver together form a complex and unique
immune microenvironment, and preclinical models have demonstrated the importance of …