Computational modeling of blood flow hemodynamics for biomechanical investigation of cardiac development and disease
The heart is the first functional organ in a develo** embryo. Cardiac development
continues throughout developmental stages while the heart goes through a serious of …
continues throughout developmental stages while the heart goes through a serious of …
Mending a broken heart: In vitro, in vivo and in silico models of congenital heart disease
Birth defects contribute to∼ 0.3% of global infant mortality in the first month of life, and
congenital heart disease (CHD) is the most common birth defect among newborns …
congenital heart disease (CHD) is the most common birth defect among newborns …
Fluid mechanical effects of fetal aortic valvuloplasty for cases of critical aortic stenosis with evolving hypoplastic left heart syndrome
Fetuses with critical aortic stenosis (FAS) are at high risk of progression to HLHS by the time
of birth (and are thus termed “evolving HLHS”). An in-utero catheter-based intervention, fetal …
of birth (and are thus termed “evolving HLHS”). An in-utero catheter-based intervention, fetal …
A pilot study of bladder voiding with real-time MRI and computational fluid dynamics
Lower urinary track symptoms (LUTS) affect many older adults. Multi-channel urodynamic
studies provide information about bladder pressure and urinary flow but offer little insight …
studies provide information about bladder pressure and urinary flow but offer little insight …
Patient-specific CFD simulation of intraventricular haemodynamics based on 3D ultrasound imaging
Background The goal of this paper is to present a computational fluid dynamic (CFD) model
with moving boundaries to study the intraventricular flows in a patient-specific framework …
with moving boundaries to study the intraventricular flows in a patient-specific framework …
Patient-specific CFD models for intraventricular flow analysis from 3D ultrasound imaging: Comparison of three clinical cases
Background As the intracardiac flow field is affected by changes in shape and motility of the
heart, intraventricular flow features can provide diagnostic indications. Ventricular flow …
heart, intraventricular flow features can provide diagnostic indications. Ventricular flow …
Human fetal hearts with tetralogy of Fallot have altered fluid dynamics and forces
Studies have suggested the effect of blood flow forces in pathogenesis and progression of
some congenital heart malformations. It is therefore of interest to study the fluid mechanic …
some congenital heart malformations. It is therefore of interest to study the fluid mechanic …
Hemodynamic and structural comparison of human fetal heart development between normally growing and hypoplastic left heart syndrome-diagnosed hearts
Congenital heart defects (CHDs) affect a wide range of societies with an incidence rate of
1.0–1.2%. These defects initiate at the early developmental stage and result in critical health …
1.0–1.2%. These defects initiate at the early developmental stage and result in critical health …
Fluid mechanics of human fetal right ventricles from image-based computational fluid dynamics using 4D clinical ultrasound scans
There are 0.6–1.9% of US children who were born with congenital heart malformations.
Clinical and animal studies suggest that abnormal blood flow forces might play a role in …
Clinical and animal studies suggest that abnormal blood flow forces might play a role in …
Quantifying blood flow dynamics during cardiac development: demystifying computational methods
K Courchaine, S Rugonyi - Philosophical Transactions of …, 2018 - royalsocietypublishing.org
Blood flow conditions (haemodynamics) are crucial for proper cardiovascular development.
Indeed, blood flow induces biomechanical adaptations and mechanotransduction signalling …
Indeed, blood flow induces biomechanical adaptations and mechanotransduction signalling …