The immunopathogenesis of narcolepsy type 1
Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …
“World in motion”–emulsion adjuvants rising to meet the pandemic challenges
Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as
key components of licensed vaccines, with over 100 million doses administered to diverse …
key components of licensed vaccines, with over 100 million doses administered to diverse …
Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …
[HTML][HTML] Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases
C Saggau, P Bacher, D Esser, M Rasa, S Meise… - Immunity, 2024 - cell.com
Pro-inflammatory autoantigen-specific CD4+ T helper (auto-Th) cells are central
orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in …
orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in …
Guillain-Barré syndrome: expanding the concept of molecular mimicry
JD Laman, R Huizinga, GJ Boons, BC Jacobs - Trends in immunology, 2022 - cell.com
Guillain-Barré syndrome (GBS) is a rapidly progressive, monophasic, and potentially
devastating immune-mediated neuropathy in humans. Preceding infections trigger the …
devastating immune-mediated neuropathy in humans. Preceding infections trigger the …
Predicting cross-reactivity and antigen specificity of T cell receptors
Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation
Narcolepsy is a rare chronic neurological disorder characterized by an irresistible excessive
daytime sleepiness and cataplexy. The disease is considered to be the result of the selective …
daytime sleepiness and cataplexy. The disease is considered to be the result of the selective …
Advances in adjuvanted influenza vaccines
S Shichinohe, T Watanabe - Vaccines, 2023 - mdpi.com
The numerous influenza infections that occur every year present a major public health
problem. Influenza vaccines are important for the prevention of the disease; however, their …
problem. Influenza vaccines are important for the prevention of the disease; however, their …
Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
A Vuorela, TL Freitag, K Leskinen, H Pessa… - Nature …, 2021 - nature.com
Abstract Narcolepsy type 1 (NT1) is a chronic neurological disorder having a strong
association with HLA-DQB1* 0602, thereby suggesting an immunological origin. Increased …
association with HLA-DQB1* 0602, thereby suggesting an immunological origin. Increased …
Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles
A Becerra-Artiles, JM Calvo-Calle, PP Nanaware… - Cell Reports, 2022 - cell.com
Sequence homology between SARS-CoV-2 and common-cold human coronaviruses
(HCoVs) raises the possibility that memory responses to prior HCoV infection can affect T …
(HCoVs) raises the possibility that memory responses to prior HCoV infection can affect T …