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Origins and evolution of CRISPR-Cas systems
CRISPR-Cas, the bacterial and archaeal adaptive immunity systems, encompass a complex
machinery that integrates fragments of foreign nucleic acids, mostly from mobile genetic …
machinery that integrates fragments of foreign nucleic acids, mostly from mobile genetic …
Functional long non-coding RNAs evolve from junk transcripts
Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …
Pentatricopeptide repeat proteins in plants
Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land
plants, with more than 400 members in most species. Over the past decade, much has been …
plants, with more than 400 members in most species. Over the past decade, much has been …
Plant organellar RNA maturation
Plant organellar RNA metabolism is run by a multitude of nucleus-encoded RNA-binding
proteins (RBPs) that control RNA stability, processing, and degradation. In chloroplasts and …
proteins (RBPs) that control RNA stability, processing, and degradation. In chloroplasts and …
Mitochondrial and plastid genome architecture: reoccurring themes, but significant differences at the extremes
Mitochondrial and plastid genomes show a wide array of architectures, varying immensely in
size, structure, and content. Some organelle DNAs have even developed elaborate …
size, structure, and content. Some organelle DNAs have even developed elaborate …
Origin of complexity in haemoglobin evolution
Most proteins associate into multimeric complexes with specific architectures,, which often
have functional properties such as cooperative ligand binding or allosteric regulation. No …
have functional properties such as cooperative ligand binding or allosteric regulation. No …
Structure of the yeast mitochondrial large ribosomal subunit
Mitochondria have specialized ribosomes that have diverged from their bacterial and
cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large …
cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large …
The on‐again, off‐again relationship between mitochondrial genomes and species boundaries
The study of reproductive isolation and species barriers frequently focuses on mitochondrial
genomes and has produced two alternative and almost diametrically opposed narratives. On …
genomes and has produced two alternative and almost diametrically opposed narratives. On …
Is junk DNA bunk? A critique of ENCODE
Do data from the Encyclopedia Of DNA Elements (ENCODE) project render the notion of
junk DNA obsolete? Here, I review older arguments for junk grounded in the C-value …
junk DNA obsolete? Here, I review older arguments for junk grounded in the C-value …
It's the song, not the singer: an exploration of holobiosis and evolutionary theory
That holobionts (microbial communities and their animal or plant hosts) are units of selection
squares poorly with the observation that microbes are often recruited (horizontally acquired) …
squares poorly with the observation that microbes are often recruited (horizontally acquired) …