The cancer-immunity cycle provides a framework to understand the series of events that
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …

Cholangiocarcinoma is the second most common primary liver cancer. Its incidence is low in
the Western world but is rising globally. Surgery, chemotherapy and radiation therapy have …

Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

The innate immune compartment of the human central nervous system (CNS) is highly
diverse and includes several immune-cell populations such as macrophages that are …

Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of
glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that …

Brain macrophages include microglia in the parenchyma, border-associated macrophages
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …