The development of reversibly binding radioligands for imaging brain proteins in vivo, such
as enzymes, neurotransmitter transporters, receptors and ion channels, with positron …

Phase 0 approaches—which include microdosing—evaluate subtherapeutic exposures of
new drugs in first-in-human studies known as exploratory clinical trials. Recent progress …

Purpose More than 15 years have passed since the first description of the unbound brain-to-
plasma partition coefficient (Kp, uu, brain) by Prof. Margareta Hammarlund-Udenaes, which …

Antipsychotics, risperidone, and risperidone's active metabolite, paliperidone (9-
hydroxyrisperidone), are related molecules used for the treatment of schizophrenia and …

Stem cell therapy holds promise for tissue regeneration, yet significant challenges persist.
Emerging as a safer and potentially more effective alternative, extracellular vesicles (EVs) …

In 2001 the molecular genetic basis of so‐called “ivermectin sensitivity” in herding breed
dogs was determined to be a P‐glycoprotein deficiency caused by a genetic variant of the …

Abluminal or luminal localization of transporter in plasma membranes at the blood–brain
barrier (BBB) is critical for their physiological and pharmacological roles. Therefore, the …

Anchovy (Engraulis japonicus) cooking wastewater (ACWW) is a by-product resulted from
the production of boiled–dried anchovies in the seafood processing industry. In this study …

Highlights•The development of radioligands for imaging of the brain with PET is
discussed.•The in vitro and preclinical evaluation of candidate radioligands is described.• …

Today, a growing number of nanotherapeutics is utilized to deliver poorly soluble
compounds using the intravenous route of administration. The drug release and the direct …