DNA methylation: roles in mammalian development
ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …
mammalian development. Although the methylation status of most CpG dinucleotides in the …
Interferons and proinflammatory cytokines in pregnancy and fetal development
Successful pregnancy requires carefully-coordinated communications between the mother
and fetus. Immune cells and cytokine signaling pathways participate as mediators of these …
and fetus. Immune cells and cytokine signaling pathways participate as mediators of these …
An efficient KRAB domain for CRISPRi applications in human cells
Clustered regularly interspaced short palindromic repeat interference (CRISPRi), based on
the fusion of inactive Cas9 (dCas9) to the Krüppel-associated box (KRAB) repressor, is a …
the fusion of inactive Cas9 (dCas9) to the Krüppel-associated box (KRAB) repressor, is a …
DNA methylation dynamics of the human preimplantation embryo
In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and
stably distributed across the genome, with local, cell-type-specific regulation directed by …
stably distributed across the genome, with local, cell-type-specific regulation directed by …
KAP1 controls endogenous retroviruses in embryonic stem cells
HM Rowe, J Jakobsson, D Mesnard, J Rougemont… - Nature, 2010 - nature.com
More than forty per cent of the mammalian genome is derived from retroelements, of which
about one-quarter are endogenous retroviruses (ERVs). Some are still active, notably in …
about one-quarter are endogenous retroviruses (ERVs). Some are still active, notably in …
KRAB zinc finger proteins
Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of
transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB …
transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB …
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions
S Quenneville, G Verde, A Corsinotti, A Kapopoulou… - Molecular cell, 2011 - cell.com
The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during
early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57 …
early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57 …
A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints
X Li, M Ito, F Zhou, N Youngson, X Zuo, P Leder… - Developmental cell, 2008 - cell.com
The mechanisms responsible for maintaining genomic methylation imprints in mouse
embryos are not understood. We generated a knockout mouse in the Zfp57 locus encoding …
embryos are not understood. We generated a knockout mouse in the Zfp57 locus encoding …
The role of KRAB-ZFPs in transposable element repression and mammalian evolution
Kruppel-associated box zinc-finger proteins (KRAB-ZFPs) make up the largest family of
transcription factors in humans. These proteins emerged in the last common ancestor of …
transcription factors in humans. These proteins emerged in the last common ancestor of …
KRAB–zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading
Krüppel-associated box domain-zinc finger proteins (KRAB–ZFPs) are tetrapod-specific
transcriptional repressors encoded in the hundreds by the human genome. In order to …
transcriptional repressors encoded in the hundreds by the human genome. In order to …