The rise of antimicrobial resistance, particularly from extended-spectrum β-lactamase
producing Enterobacteriaceae (ESBL-E), poses a significant global health challenge as it …

The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …

Gram-negative bacteria pose a major threat to human health in an era fraught with multi-
drug resistant bacterial infections. Despite extensive drug discovery campaigns over the …

Multidrug-resistant (MDR) Escherichia coli strains have rapidly increased worldwide, and
effective antibiotic therapeutic options are becoming more restricted. As a polymyxin …

Nickel uptake and cellular compartmentation were investigated in three Ni
hyperaccumulators: Alyssum bertolonii (Desv), Alyssum lesbiacum (Candargy) and Thlaspi …

Background Mobile colistin resistance (mcr) genes modify Lipid A molecules of the
lipopolysaccharide, changing the overall charge of the outer membrane. Results and …

Polymyxins (polymyxin B and colistin) are last-line antibiotics against multidrug-resistant
Gram-negative pathogens. Polymyxin resistance is increasing worldwide, with resistance …

The spread of carbapenem-and polymyxin-resistant Enterobacteriaceae poses a significant
threat to public health, challenging clinicians worldwide with limited therapeutic options. This …

A wide variety of antibiotics are targeted to the bacterial membrane due to its unique
arrangement and composition relative to the host mammalian membranes. By modification …

Background Beyond plasmid-encoded resistance (mcr genes) prevalence in strain
collections, large epidemiological studies to estimate the human burden of colistin-resistant …