1. INTRODUCTION Despite being largely absent from natural products and biological
processes, fluorine plays a conspicuous and increasingly important role within …

Method B 692 3.7. Selective Trifluoromethylation of Multi-Functional Substrates 693 3.8.
Enantioselective Trifluoromethylation 695 3.8. 1. Aldehydes and Ketones: With Cinchona …

Organosilicon compounds act as a nucleophile upon activation by an appropriate base and
behave in a manner similar to main-group organometallic reagents. In the last decades …

1. INTRODUCTION “All new is well-forgotten old”, the proverb goes. The current “fluorine
boom” 1 is news only to a novice in the field: the exceptional importance of fluorinated …

In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area
of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of …

Very few fields in chemistry have shown such a considerable interest as fluoroorganic
chemistry. Fluorine is perhaps the element that has experienced the greatest recent interest …

Currently, the chemistry of organofluorine compounds is a leading and rapidly develo**
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

The first enantioselective, organocatalytic α-trifluoromethylation and α-perfluoroalkylation of
aldehydes have been accomplished using a readily available iridium photocatalyst and a …

Abstract The legacy of Gilbert Newton Lewis (1875–1946) pervades the lexicon of chemical
bonding and reactivity. The power of his concept of donor–acceptor bonding is evident in the …

The direct trifluoromethylation of (hetero) arenes is a process of high importance to the
pharmaceutical industry. Many reagents exist for this purpose and have found widespread …