This paper makes five key points. First is that the aggregate effect of radical and sustained
behavioural changes in a sufficient number of individuals potentially at risk is needed for …

The HIV/AIDS pandemic has become part of the contemporary global landscape. Few
predicted its effect on mortality and morbidity or its devastating social and economic …

Background The use of antiviral medications by HIV negative people to prevent acquisition
of HIV or pre-exposure prophylaxis (PrEP) has shown promising results in recent trials. To …

A quarter of a century of AIDS responses has created a huge body of knowledge about HIV
transmission and how to prevent it, yet every day, around the world, nearly 7000 people …

Intensive research efforts for more than two decades have not yet resulted in an HIV vaccine
of even moderate effectiveness. However, some progress has been made with other …

Evidence-informed and human rights-based combination prevention combines behavioural,
biomedical, and structural interventions to address both the immediate risks and underlying …

Large declines in HIV incidence have been reported since 2001, and scientific advances in
HIV prevention provide strong hope to reduce incidence further. Now is the time to replace …

Stigma and discrimination within health care settings remain a public health challenge
across diverse cultural environments and may have deleterious effects on mental and …

Improvements in context-specific programming are essential to address HIV and other
sexually transmitted and blood-borne infection epidemics globally. A programme science …

Background After more than 25 years, public health programs have not been able to
sufficiently reduce the number of new HIV infections. Over 7,000 people become infected …