The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …

RNA has sparked a revolution in modern medicine, with the potential to transform the way
we treat diseases. Recent regulatory approvals, hundreds of new clinical trials, the …

Use of tumor-suppressive microRNAs (miRNAs) as anti-cancer agents is hindered by the
lack of effective delivery vehicles, entrapment of the miRNA within endocytic compartments …

Abstract microRNA (miRNA) mimics are an emerging class of oligonucleotide therapeutics,
with a few compounds already in clinical stages. Synthetic miRNAs are able to restore …

The p53 gene is one of the genes most closely associated with human tumors and has
become a popular target for tumor drug design. Currently, p53-based gene therapy …

High-grade serous ovarian cancer (HGSC) is the most common subtype of ovarian cancer.
HGSC patients typically present with advanced disease, which is often resistant to …

Prostate cancer (PCa) remains a common cancer with high mortality in men due to its
heterogeneity and the emergence of drug resistance. A critical factor contributing to its …

Delivery systems play a crucial role in RNA therapy. However, the current RNA delivery
system involves complex preparation and transport processes, requiring RNA preassembly …

During all periods of male ontogenesis, physiological processes responsible for the correct
functioning of reproductive organs and spermatogenesis are under the influence of various …

A rapid emergence of small interfering ribonucleic acid (siRNA) is witnessed as a powerful
tool in gene therapy for suppressing gene expression. Since highly porous metal‐organic …