ECM in differentiation: a review of matrix structure, composition and mechanical properties
Stem cell regenerative potential owing to the capacity to self-renew as well as differentiate
into other cell types is a promising avenue in regenerative medicine. Stem cell niche not …
into other cell types is a promising avenue in regenerative medicine. Stem cell niche not …
Microenvironmental control of adipocyte fate and function
The properties of tissue-specific microenvironments vary widely in the human body and
demonstrably influence the structure and function of many cell types. Adipocytes are no …
demonstrably influence the structure and function of many cell types. Adipocytes are no …
Collagens regulating adipose tissue formation and functions
I Jääskeläinen, T Petäistö, E Mirzarazi Dahagi… - Biomedicines, 2023 - mdpi.com
The globally increasing prevalence of obesity is associated with the development of
metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Excess adipose …
metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Excess adipose …
When Mechanical Stress Matters: Generation of Polyploid Giant Cancer Cells in Tumor‐Like Microcapsules
Y Antonelli, R Krüger, A Buehler… - Advanced Functional …, 2024 - Wiley Online Library
Biofabrication techniques enable the performance of bioinspired three‐dimensional (3D)
matrices resembling primary tumors. To validate their reliability, embedded cells may …
matrices resembling primary tumors. To validate their reliability, embedded cells may …
Adipose tissue development relies on coordinated extracellular matrix remodeling, angiogenesis, and adipogenesis
EK Johnston, RD Abbott - Biomedicines, 2022 - mdpi.com
Despite develo** prenatally, the adipose tissue is unique in its ability to undergo drastic
growth even after reaching its mature size. This development and subsequent maintenance …
growth even after reaching its mature size. This development and subsequent maintenance …
Cytoskeleton and plasma-membrane damage resulting from exposure to sustained deformations: a review of the mechanobiology of chronic wounds
The purpose of this review paper is to summarize the current knowledge on cell-scale
mechanically-inflicted deformation-damage, which is at the frontier of cell mechanobiology …
mechanically-inflicted deformation-damage, which is at the frontier of cell mechanobiology …
Metastatic breast cancer cells adhere strongly on varying stiffness substrates, initially without adjusting their morphology
S Massalha, D Weihs - Biomechanics and Modeling in Mechanobiology, 2017 - Springer
We show that metastatic breast cancer cells are quantitatively identifiable from benign cells
during adherence onto soft, elastic gels. We identify differences in time-dependent …
during adherence onto soft, elastic gels. We identify differences in time-dependent …
Effect of 3D printed polycaprolactone scaffold with a bionic structure on the early stage of fat grafting
W Bao, L Cao, H Wei, D Zhu, G Zhou, J Wang… - Materials Science and …, 2021 - Elsevier
Mature adipocytes are sensitive to stress and hypoxia, which are the two major obstacles in
large-volume fat grafting. Bionic scaffolds are considered beneficial for fat grafting; however …
large-volume fat grafting. Bionic scaffolds are considered beneficial for fat grafting; however …
Proximity of metastatic cells enhances their mechanobiological invasiveness
Y Merkher, D Weihs - Annals of biomedical engineering, 2017 - Springer
A critical step in metastases formation is cancer-cell invasion through tissue. During
invasion, cells change morphology and apply forces to their surroundings. We have …
invasion, cells change morphology and apply forces to their surroundings. We have …
Maturation of adipocytes is suppressed by fluid shear stress
Preadipocytes are mechano-responsive cells and their differentiation to adipocytes may be
regulated by various types of physical stimulation. Understanding the mechanism of …
regulated by various types of physical stimulation. Understanding the mechanism of …