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Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies
M Moradi, A Mousavi, Z Emamgholipour… - European Journal of …, 2023 - Elsevier
Angiogenesis, the formation of new blood vessels from the existing vasculature, is pivotal in
the migration, growth, and differentiation of endothelial cells in normal physiological …
the migration, growth, and differentiation of endothelial cells in normal physiological …
Recent development of VEGFR small molecule inhibitors as anticancer agents: A patent review (2021–2023)
J Zeng, Q Deng, Z Chen, S Yan, Q Dong, Y Zhang… - Bioorganic …, 2024 - Elsevier
VEGFR, a receptor tyrosine kinase inhibitor (TKI), is an important regulatory factor that
promotes angiogenesis and vascular permeability. It plays a significant role in processes …
promotes angiogenesis and vascular permeability. It plays a significant role in processes …
Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties
In the current medical era, the utilization of a single small molecule to simultaneously target
two distinct molecular targets is emerging as a highly effective strategy in the battle against …
two distinct molecular targets is emerging as a highly effective strategy in the battle against …
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
New theobromine derivative as apoptotic anti-triple-negative breast cancer targeting EGFR protein: CADD story
A new EGFR inhibitor has been developed from theobromine (meta methoxy phenyl)
acetamide derivative), T-1-MMPA, exhibited the essential pharmacophoric characteristics …
acetamide derivative), T-1-MMPA, exhibited the essential pharmacophoric characteristics …
Novel promising benzoxazole/benzothiazole‐derived immunomodulatory agents: Design, synthesis, anticancer evaluation, and in silico ADMET analysis
Eleven novel benzoxazole/benzothiazole‐based thalidomide analogs were designed and
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
Novel imidazo [2, 1-b] thiazoles and imidazo [1, 2-a] pyridines tethered with indolinone motif as VEGFR-2 inhibitors and apoptotic inducers: Design, synthesis and …
The current study investigates the anticancer and VEGFR-2 inhibitory activities of 16 novel
indolinone-grafted imidazo [2, 1-b] thiazole and imidazo [1, 2-a] pyridine derivatives (6a-h …
indolinone-grafted imidazo [2, 1-b] thiazole and imidazo [1, 2-a] pyridine derivatives (6a-h …
1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as novel anticancer agents: synthesis, biological evaluation and molecular modeling insights
Human health is experiencing several obstacles in the modern medical era, particularly
cancer. As a result, the cancer therapeutic arsenal should be continually expanded with …
cancer. As a result, the cancer therapeutic arsenal should be continually expanded with …
Unveiling the potential of isatin-grafted phenyl-1, 2, 3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments
The use of VEGFR-2 inhibitors as a stand-alone treatment has proven to be ineffective in
clinical trials due to the robustness of cellular response loops that lead to treatment …
clinical trials due to the robustness of cellular response loops that lead to treatment …
New theobromine derivatives inhibiting VEGFR-2: design, synthesis, antiproliferative, docking and molecular dynamics simulations
Background: VEGFR-2 is one of the most effective targets in cancer treatment. Aim: The
design and semi-synthesis of new theobromine derivatives as potential VEGFR-2 inhibitors …
design and semi-synthesis of new theobromine derivatives as potential VEGFR-2 inhibitors …