The vascularization paradox of non-union formation
MM Menger, MW Laschke, AK Nussler, MD Menger… - Angiogenesis, 2022 - Springer
Despite major research efforts to elucidate mechanisms of non-union formation, failed
fracture healing remains a common complication in orthopedic surgery. Adequate …
fracture healing remains a common complication in orthopedic surgery. Adequate …
[PDF][PDF] Tissue engineering and regenerative approaches to improving the healing of large bone defects
Despite the high innate regenerative capacity of bone, large osseous defects fail to heal and
remain a clinical challenge. Healing such defects requires the formation of large amounts of …
remain a clinical challenge. Healing such defects requires the formation of large amounts of …
Regeneration of rat sciatic nerve using PLGA conduit containing rat ADSCs with controlled release of BDNF and gold nanoparticles
Implantation of a nerve guidance conduit (NGC) carrying neuroprotective factors is
promising for repairing peripheral nerve injury. Here, we developed a novel strategy for …
promising for repairing peripheral nerve injury. Here, we developed a novel strategy for …
Biomaterial-mediated strategies targeting vascularization for bone repair
Repair of non-healing bone defects through tissue engineering strategies remains a
challenging feat in the clinic due to the aversive microenvironment surrounding the injured …
challenging feat in the clinic due to the aversive microenvironment surrounding the injured …
The use of a novel bone allograft wash process to generate a biocompatible, mechanically stable and osteoinductive biological scaffold for use in bone tissue …
CA Smith, SM Richardson, MJ Eagle… - Journal of tissue …, 2015 - Wiley Online Library
Fresh‐frozen biological allograft remains the most effective substitute for the 'gold
standard'autograft, sharing many of its osteogenic properties but, conversely, lacking viable …
standard'autograft, sharing many of its osteogenic properties but, conversely, lacking viable …
Comparison of stromal vascular fraction and passaged adipose-derived stromal/stem cells as point-of-care agents for bone regeneration
Large craniofacial bone defects remain a clinical challenge due to their complex shapes and
large volumes. Stem cell-based technologies that deliver osteogenic stem cells have shown …
large volumes. Stem cell-based technologies that deliver osteogenic stem cells have shown …
Human umbilical vein endothelial cell support bone formation of adipose-derived stem cell-loaded and 3D-printed osteogenic matrices in the arteriovenous loop …
S Winkler, H Mutschall, J Biggemann, T Fey… - … Engineering Part A, 2021 - liebertpub.com
Introduction: For the regeneration of large volume tissue defects, the interaction between
angiogenesis and osteogenesis is a crucial prerequisite. The surgically induced …
angiogenesis and osteogenesis is a crucial prerequisite. The surgically induced …
Engineering clinically relevant volumes of vascularized bone
Vascularization remains one of the most important challenges that must be overcome for
tissue engineering to be consistently implemented for reconstruction of large volume bone …
tissue engineering to be consistently implemented for reconstruction of large volume bone …
Preparation and evaluation of polyurethane/cellulose nanowhisker bimodal foam nanocomposites for osteogenic differentiation of hMSCs
Biocompatible and biodegradable polyurethanes (PUs) based on polycaprolactone diol
(PCL) were prepared and filled with cellulose nanowhiskers (CNWs) obtained from …
(PCL) were prepared and filled with cellulose nanowhiskers (CNWs) obtained from …
Preformed vascular networks survive and enhance vascularization in critical sized cranial defects
Vascular networks provide nutrients, oxygen, and progenitor cells that are essential for bone
function. It has been proposed that a preformed vascular network may enhance the …
function. It has been proposed that a preformed vascular network may enhance the …