Glucose transporters as a target for anticancer therapy
Simple Summary For mammalian cells, glucose is a major source of energy. In the presence
of oxygen, a complete breakdown of glucose generates 36 molecules of ATP from one …
of oxygen, a complete breakdown of glucose generates 36 molecules of ATP from one …
Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment
It is long recognized that cancer cells display increased glucose uptake and metabolism. In
a rate-limiting step for glucose metabolism, the glucose transporter (GLUT) proteins facilitate …
a rate-limiting step for glucose metabolism, the glucose transporter (GLUT) proteins facilitate …
AMPK modulates Hippo pathway activity to regulate energy homeostasis
The Hippo pathway was discovered as a conserved tumour suppressor pathway restricting
cell proliferation and apoptosis. However, the upstream signals that regulate the Hippo …
cell proliferation and apoptosis. However, the upstream signals that regulate the Hippo …
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake
WA Flavahan, Q Wu, M Hitomi, N Rahim, Y Kim… - Nature …, 2013 - nature.com
Like all cancers, brain tumors require a continuous source of energy and molecular
resources for new cell production. In normal brain, glucose is an essential neuronal fuel, but …
resources for new cell production. In normal brain, glucose is an essential neuronal fuel, but …
Expression of glucose transporters in cancers
L Szablewski - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2013 - Elsevier
It has been known for 80years that cancer cell growth in an energy-related process
supported by an increased glucose metabolism. This phenomenon suggests a need for a …
supported by an increased glucose metabolism. This phenomenon suggests a need for a …
Glut 1 in cancer cells and the inhibitory action of resveratrol as a potential therapeutic strategy
A Zambrano, M Molt, E Uribe, M Salas - International journal of molecular …, 2019 - mdpi.com
An important hallmark in cancer cells is the increase in glucose uptake. GLUT1 is an
important target in cancer treatment because cancer cells upregulate GLUT1, a membrane …
important target in cancer treatment because cancer cells upregulate GLUT1, a membrane …
Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review
PE Porporato, S Dhup, RK Dadhich, T Copetti… - Frontiers in …, 2011 - frontiersin.org
Cancer is a metabolic disease and the solution of two metabolic equations: to produce
energy with limited resources and to fulfill the biosynthetic needs of proliferating cells. Both …
energy with limited resources and to fulfill the biosynthetic needs of proliferating cells. Both …
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters
I Marchiq, J Pouysségur - Journal of molecular medicine, 2016 - Springer
Abstract Since Otto Warburg reported the 'addiction'of cancer cells to fermentative glycolysis,
a metabolic pathway that provides energy and building blocks, thousands of studies have …
a metabolic pathway that provides energy and building blocks, thousands of studies have …
Inhibition of glucose transporters and glutaminase synergistically impairs tumor cell growth
ES Reckzeh, G Karageorgis, M Schwalfenberg… - Cell chemical …, 2019 - cell.com
Cancer cells sustain growth by altering their metabolism to accelerated aerobic glycolysis
accompanied by increased glucose demand and employ glutamine as additional nutrient …
accompanied by increased glucose demand and employ glutamine as additional nutrient …
Altered cancer metabolism in mechanisms of immunotherapy resistance
R Ramapriyan, MS Caetano, HB Barsoumian… - Pharmacology & …, 2019 - Elsevier
Many metabolic alterations, including the Warburg effect, occur in cancer cells that influence
the tumor microenvironment, including switching to glycolysis from oxidative …
the tumor microenvironment, including switching to glycolysis from oxidative …