The NMDA receptor and schizophrenia: from pathophysiology to treatment
DT Balu - Advances in pharmacology, 2016 - Elsevier
Schizophrenia is a severe mental illness that affects almost 1% of the population worldwide.
Even though the etiology of schizophrenia is uncertain, it is believed to be a …
Even though the etiology of schizophrenia is uncertain, it is believed to be a …
NMDA receptor encephalitis and other antibody-mediated disorders of the synapse: The 2016 Cotzias Lecture
J Dalmau - Neurology, 2016 - AAN Enterprises
Investigations during the last 10 years have revealed a group of disorders mediated by
antibodies against ion channels and synaptic receptors, which cause both neurologic and …
antibodies against ion channels and synaptic receptors, which cause both neurologic and …
GluN2A mediates ketamine-induced rapid antidepressant-like responses
T Su, Y Lu, C Fu, Y Geng, Y Chen - Nature Neuroscience, 2023 - nature.com
Ketamine was thought to induce rapid antidepressant responses by inhibiting GluN2B-
containing N-methyl-d-aspartic acid (NMDA) receptors (NMDARs), which presents a …
containing N-methyl-d-aspartic acid (NMDA) receptors (NMDARs), which presents a …
NMDAR hypofunction animal models of schizophrenia
The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained
antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that …
antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that …
Impaired tuning of neural ensembles and the pathophysiology of schizophrenia: a translational and computational neuroscience perspective
The functional optimization of neural ensembles is central to human higher cognitive
functions. When the functions through which neural activity is tuned fail to develop or break …
functions. When the functions through which neural activity is tuned fail to develop or break …
Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia
E Parellada, P Gassó - Translational psychiatry, 2021 - nature.com
Schizophrenia disorder remains an unsolved puzzle. However, the integration of recent
findings from genetics, molecular biology, neuroimaging, animal models and translational …
findings from genetics, molecular biology, neuroimaging, animal models and translational …
[HTML][HTML] A quantitative review of the postmortem evidence for decreased cortical N-methyl-D-aspartate receptor expression levels in schizophrenia: How can we link …
Evidence suggests that anomalous mismatch negativity (MMN) in schizophrenia is related to
glutamatergic abnormalities, possibly involving N-methyl-d-aspartate (NMDA) receptors …
glutamatergic abnormalities, possibly involving N-methyl-d-aspartate (NMDA) receptors …
Abnormal gamma oscillations in N-methyl-D-aspartate receptor hypofunction models of schizophrenia
N-methyl-D-aspartate receptor (NMDAR) hypofunction in parvalbumin-expressing (PV+)
inhibitory neurons (INs) may contribute to symptoms in patients with schizophrenia (SZ). This …
inhibitory neurons (INs) may contribute to symptoms in patients with schizophrenia (SZ). This …
Alterations of auditory-evoked gamma oscillations are more pronounced than alterations of spontaneous power of gamma oscillation in early stages of schizophrenia
Several animal models of schizophrenia and patients with chronic schizophrenia have
shown increased spontaneous power of gamma oscillations. However, the most robust …
shown increased spontaneous power of gamma oscillations. However, the most robust …